Pascal Bonnet
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Explore the profile of Pascal Bonnet including associated specialties, affiliations and a list of published articles.
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74
Citations
620
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Recent Articles
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2.
Bournez C, Gally J, Aci-Seche S, Bernard P, Bonnet P
Mol Inform
. 2024 Jun;
43(9):e202300335.
PMID: 38864978
Natural products have long been an important source of inspiration for medicinal chemistry and drug discovery. In the cosmetic field, they remain the major elements of the composition and serve...
3.
Ziada S, Diharce J, Serillon D, Bonnet P, Aci-Seche S
Int J Mol Sci
. 2024 May;
25(10).
PMID: 38791449
Dysregulation of cyclin-dependent kinase 8 (CDK8) activity has been associated with many diseases, including colorectal and breast cancer. As usual in the CDK family, the activity of CDK8 is controlled...
4.
Champire A, Berabez R, Braka A, Cosson A, Corret J, Girardin C, et al.
Eur J Med Chem
. 2024 Apr;
271:116391.
PMID: 38669909
LIM Kinases, LIMK1 and LIMK2, have become promising targets for the development of inhibitors with potential application for the treatment of several major diseases. LIMKs play crucial roles in cytoskeleton...
5.
Frossard N, Coic A, Saguet T, Coic A, Himbert F, Do Q, et al.
Int J Cosmet Sci
. 2024 Feb;
46(3):468-477.
PMID: 38326978
Background: Atopic dermatitis has a marked economic impact and affects the quality of life. A cosmetic compound with an innovative strategy is proposed here as a small chemical neutraligand, GPN279...
6.
Yaacoub K, Pedeux R, Lafite P, Jarry U, Aci-Seche S, Bonnet P, et al.
Curr Issues Mol Biol
. 2024 Jan;
46(1):710-728.
PMID: 38248348
The catalytically inactive caspase-8-homologous protein, c-FLIP, is a potent antiapoptotic protein highly expressed in various types of cancers. c-FLIP competes with caspase-8 for binding to the adaptor protein FADD (Fas-Associated...
7.
Libouban P, Aci-Seche S, Gomez-Tamayo J, Tresadern G, Bonnet P
Int J Mol Sci
. 2023 Nov;
24(22).
PMID: 38003312
Artificial intelligence (AI) has gained significant traction in the field of drug discovery, with deep learning (DL) algorithms playing a crucial role in predicting protein-ligand binding affinities. Despite advancements in...
8.
Aci-Seche S, Bourg S, Bonnet P, Rebehmed J, de Brevern A, Diharce J
Data Brief
. 2023 Jul;
49:109386.
PMID: 37492229
Computational approaches are nowadays largely applied in drug discovery projects. Among these, molecular docking is the most used for hit identification against a drug target protein. However, many scientists in...
9.
Arora R, Linders J, Aci-Seche S, Verheyen T, Van Heerde E, Brehmer D, et al.
Eur J Med Chem
. 2023 Mar;
250:115231.
PMID: 36878151
The mutation V600E in B-Raf leads to mitogen activated protein kinase (MAPK) pathway activation, uncontrolled cell proliferation, and tumorigenesis. ATP competitive type I B-Raf inhibitors, such as vemurafenib (1) and...
10.
Ziada S, Diharce J, Raimbaud E, Aci-Seche S, Ducrot P, Bonnet P
J Chem Inf Model
. 2022 Nov;
62(22):5536-5549.
PMID: 36350238
Drug-target residence time has emerged as a key selection factor in drug discovery since the binding duration of a drug molecule to its protein target can significantly impact its efficacy....