Dimitris P Xirodimas
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Explore the profile of Dimitris P Xirodimas including associated specialties, affiliations and a list of published articles.
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41
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1883
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Recent Articles
1.
Brunello L, Polanowska J, Le Tareau L, Maghames C, Georget V, Guette C, et al.
EMBO J
. 2024 Dec;
44(3):801-823.
PMID: 39690241
The identification of pathways that control elimination of protein inclusions is essential to understand the cellular response to proteotoxicity, particularly in the nuclear compartment, for which our knowledge is limited....
2.
Bou Malhab L, Schmidt S, Fagotto-Kaufmann C, Pion E, Gadea G, Roux P, et al.
Cells
. 2024 Oct;
13(19.
PMID: 39404389
Mdmx (Mdm4) is established as an oncogene mainly through repression of the p53 tumour suppressor. On the other hand, anti-oncogenic functions for Mdmx have also been proposed, but the underlying...
3.
Aubry A, Pearson J, Charish J, Yu T, Sivak J, Xirodimas D, et al.
Cell Rep
. 2024 Jan;
43(2):113711.
PMID: 38236775
No abstract available.
4.
Aubry A, Pearson J, Charish J, Yu T, Sivak J, Xirodimas D, et al.
Cell Rep
. 2023 Aug;
42(8):112925.
PMID: 37552601
The neddylation inhibitor MLN4924/Pevonedistat is in clinical trials for multiple cancers. Efficacy is generally attributed to cullin RING ligase (CRL) inhibition, but the contribution of non-CRL targets is unknown. Here,...
5.
Kassouf T, Shrivastava R, Meszka I, Bailly A, Polanowska J, Trauchessec H, et al.
Sci Adv
. 2023 Mar;
9(13):eabq7585.
PMID: 37000881
The elimination of aberrant inclusions is regarded as a therapeutic approach in neurodegeneration. In amyotrophic lateral sclerosis (ALS), mutations in proteins found within cytoplasmic condensates called stress granules (SGs) are...
6.
Oliveira C, Isaakova E, Beli P, Xirodimas D
Methods Mol Biol
. 2022 Nov;
2602:137-149.
PMID: 36446972
The identification of modification sites for ubiquitin and ubiquitin-like modifiers is an essential step in the elucidation of controlled processes. The ubiquitin-like modifier NEDD8 is an important regulator of plethora...
7.
Meszka I, Polanowska J, Xirodimas D
Semin Cell Dev Biol
. 2022 Jan;
132:27-37.
PMID: 35078718
Post-translational modification of proteins with the Ubiquitin-like molecule NEDD8 is a critical regulatory mechanism for several biological processes and a potential target for therapeutic intervention. The role of NEDD8 has...
8.
Bailly A, Xirodimas D
Biochem Soc Trans
. 2021 Jun;
49(3):1075-1083.
PMID: 34156462
Molecular chaperones are essential components of the protein quality control system and maintenance of homeostasis. Heat Shock Protein 70 (HSP70), a highly evolutionarily conserved family of chaperones is a key...
9.
Serrano-Macia M, Simon J, Gonzalez-Rellan M, Azkargorta M, Goikoetxea-Usandizaga N, Lopitz-Otsoa F, et al.
Mol Metab
. 2021 Jun;
53:101275.
PMID: 34153521
Objective: Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic fatty liver disease (NAFLD). Herein, we propose...
10.
Lobato-Gil S, Heidelberger J, Maghames C, Bailly A, Brunello L, Rodriguez M, et al.
Cell Rep
. 2021 Jan;
34(3):108635.
PMID: 33472076
The ubiquitin-like molecule NEDD8 controls several biological processes and is a promising target for therapeutic intervention. NEDDylation occurs through specific NEDD8 enzymes (canonical) or enzymes of the ubiquitin system (atypical)....