Orsolya Leidecker
Overview
Explore the profile of Orsolya Leidecker including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
607
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Recent Articles
1.
Strachan J, Leidecker O, Spanos C, Le Coz C, Chapman E, Arsenijevic A, et al.
J Cell Sci
. 2023 Nov;
136(23).
PMID: 37970674
Regulation by the small modifier SUMO is heavily dependent on spatial control of enzymes that mediate the attachment and removal of SUMO on substrate proteins. Here, we show that in...
2.
Ratz L, Brambillasca C, Bartke L, Huetzen M, Goergens J, Leidecker O, et al.
Breast Cancer Res
. 2022 Jun;
24(1):41.
PMID: 35715861
Background: The majority of BRCA1-mutant breast cancers are characterized by a triple-negative phenotype and a basal-like molecular subtype, associated with aggressive clinical behavior. Current treatment options are limited, highlighting the...
3.
Bonfiglio J, Leidecker O, Dauben H, Longarini E, Colby T, San Segundo-Acosta P, et al.
Cell
. 2020 Nov;
183(4):1086-1102.e23.
PMID: 33186521
Strategies for installing authentic ADP-ribosylation (ADPr) at desired positions are fundamental for creating the tools needed to explore this elusive post-translational modification (PTM) in essential cellular processes. Here, we describe...
4.
Fatima A, Irmak D, Noormohammadi A, Rinschen M, Das A, Leidecker O, et al.
Commun Biol
. 2020 May;
3(1):262.
PMID: 32451438
Histones modulate gene expression by chromatin compaction, regulating numerous processes such as differentiation. However, the mechanisms underlying histone degradation remain elusive. Human embryonic stem cells (hESCs) have a unique chromatin...
5.
Bailly A, Perrin A, Serrano-Macia M, Maghames C, Leidecker O, Trauchessec H, et al.
Cell Rep
. 2019 Oct;
29(1):212-224.e8.
PMID: 31577950
Ubiquitin and ubiquitin-like chains are finely balanced by conjugating and de-conjugating enzymes. Alterations in this balance trigger the response to stress conditions and are often observed in pathologies. How such...
6.
Palazzo L, Leidecker O, Prokhorova E, Dauben H, Matic I, Ahel I
Elife
. 2018 Feb;
7.
PMID: 29480802
Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that synthesise ADP-ribosylation (ADPr), a reversible modification of proteins that regulates many different cellular processes. Several mammalian PARPs are known to regulate...
7.
Leidecker O, Bonfiglio J, Colby T, Zhang Q, Atanassov I, Zaja R, et al.
Nat Chem Biol
. 2016 Oct;
12(12):998-1000.
PMID: 27723750
ADP-ribosylation (ADPr) is a biologically and clinically important post-translational modification, but little is known about the amino acids it targets on cellular proteins. Here we present a proteomic approach for...
8.
Rack J, Morra R, Barkauskaite E, Kraehenbuehl R, Ariza A, Qu Y, et al.
Mol Cell
. 2015 Jul;
59(2):309-20.
PMID: 26166706
Sirtuins are an ancient family of NAD(+)-dependent deacylases connected with the regulation of fundamental cellular processes including metabolic homeostasis and genome integrity. We show the existence of a hitherto unrecognized...
9.
Palazzo L, Thomas B, Jemth A, Colby T, Leidecker O, Feijs K, et al.
Biochem J
. 2015 Mar;
468(2):293-301.
PMID: 25789582
ADP-ribosylation is a post-translational modification (PTM) of proteins found in organisms from all kingdoms of life which regulates many important biological functions including DNA repair, chromatin structure, unfolded protein response...
10.
Xu Y, Plechanovova A, Simpson P, Marchant J, Leidecker O, Kraatz S, et al.
Nat Commun
. 2014 Jun;
5:4217.
PMID: 24969970
The small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response. The SUMO-targeted ubiquitin ligase RNF4 engages...