Dietmar Steverding
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Explore the profile of Dietmar Steverding including associated specialties, affiliations and a list of published articles.
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100
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1201
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Recent Articles
1.
Steverding D, Rushworth S, Hurle G, Antoszczak M, Sulik M, Huczynski A, et al.
Molecules
. 2024 Dec;
29(23).
PMID: 39683767
Salinomycin and its derivatives display promising anti-proliferating activity against bloodstream forms of . The mechanism of trypanocidal action of these compounds is due to their ionophoretic activity inducing an influx...
2.
Steverding D, Tinson R, Piras M, Wren S, Rushworth S, Searcey M, et al.
Exp Parasitol
. 2024 Mar;
260:108744.
PMID: 38513971
Suramin was the first effective drug for the treatment of human African sleeping sickness. Structural analogues of the trypanocide have previously been shown to be potent inhibitors of several enzymes....
3.
Steverding D, Troeberg L
Parasitol Res
. 2023 Dec;
123(1):11.
PMID: 38057659
Suramin was the first drug developed using the approach of medicinal chemistry by the German Bayer company in the 1910s for the treatment of human African sleeping sickness caused by...
4.
Sulik M, Fontinha D, Steverding D, Sobczak S, Antoszczak M, Prudencio M, et al.
Eur J Med Chem
. 2023 Nov;
263:115951.
PMID: 37988797
Ivermectin is a sixteen-membered macrolactone "wonder drug" of Nobel prize-honored distinction that exhibits a wide range of antiparasitic activities. It has been used for almost four decades in the treatment...
5.
Sulik M, Antoszczak M, Huczynski A, Steverding D
Eur J Med Chem
. 2023 Oct;
261:115838.
PMID: 37793327
Parasitic diseases still pose a serious threat to human and animal health, particularly for millions of people and their livelihoods in low-income countries. Therefore, research into the development of effective...
6.
Green J, Tinson R, Betts J, Piras M, Pelut A, Steverding D, et al.
Bioorg Med Chem
. 2023 Jul;
92:117424.
PMID: 37517101
Osteoarthritis is a chronic degenerative joint disease affecting millions of people worldwide, with no disease-modifying drugs currently available to treat the disease. Tissue inhibitor of metalloproteinases 3 (TIMP-3) is a...
7.
Antoszczak M, Gadsby-Davis K, Steverding D, Huczynski A
Eur J Med Chem
. 2023 Mar;
250:115241.
PMID: 36870272
Salinomycin (SAL) is a natural polyether ionophore that exhibits a very broad spectrum of biological effects, ranging from anticancer to antiparasitic activities. Our recent studies have shown that the chemical...
8.
Steverding D, Strand D, Huczynski A
Exp Parasitol
. 2022 Oct;
243:108414.
PMID: 36273616
The naturally occurring polyether ionophore salinomycin was previously found to display promising anti-proliferative activity against bloodstream forms of Trypanosoma brucei. Here, we report the evaluation of 20-deoxysalinomycin, a naturally occurring...
9.
Steverding D, Nascimento L, Perez-Castillo Y, de Sousa D
Molecules
. 2022 Sep;
27(18).
PMID: 36144611
Eight gallic acid alkyl esters (1−8) were synthesized via Fischer esterification and evaluated for their trypanocidal and leishmanicidal activity using bloodstream forms of Trypanosoma brucei and promastigotes of Leishmania major....
10.
Steverding D
Dis Aquat Organ
. 2022 Jul;
150:87-101.
PMID: 35899962
The ciliate Philasterides dicentrarchi has been previously identified as a new agent of scuticociliatosis in marine fish. The parasite can cause high mortalities in fish reared on farms or kept...