Dharmarajan Sriram
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Explore the profile of Dharmarajan Sriram including associated specialties, affiliations and a list of published articles.
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316
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2124
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Recent Articles
1.
Dhangar M, Ahmad I, Oh J, Patil B, Chinnam S, Sriram D, et al.
ACS Med Chem Lett
. 2025 Jan;
16(1):40-50.
PMID: 39811132
Linezolid, a widely used oxazolidinone antibiotic, exhibits potent activity against resistant bacterial infections but is associated with serotonergic toxicity, primarily due to its inhibition of monoamine oxidase (MAO). MAOs, consisting...
2.
El-Shoukrofy M, Atta A, Fahmy S, Sriram D, Shehat M, Labouta I, et al.
J Enzyme Inhib Med Chem
. 2024 Sep;
39(1):2386668.
PMID: 39258667
New Biginelli adducts were rationalised, the introduction of selected anti-tubercular (TB) pharmacophores into the dihydropyrimidine (DHPM) ring of deoxythymidine monophosphate (dTMP), the natural substrate of thymidine monophosphate kinase (TMPK). Repurposing...
3.
Girase R, Ahmad I, Oh J, Mathew B, Vagolu S, Tonjum T, et al.
ACS Med Chem Lett
. 2024 Jun;
15(6):924-937.
PMID: 38894926
Serotonergic toxicity due to MAO enzyme inhibition is a significant concern when using linezolid to treat MDR-TB. To address this issue, we designed linezolid bioisosteres with a modified acetamidomethyl side...
4.
Singh M, Dhanwal A, Verma A, Augustin L, Kumari N, Chakraborti S, et al.
Sci Rep
. 2024 May;
14(1):12170.
PMID: 38806590
Tuberculosis (TB) continues to be a global health crisis, necessitating urgent interventions to address drug resistance and improve treatment efficacy. In this study, we validate lumazine synthase (RibH), a vital...
5.
Rukyanaik V, Gamidi R, Kumari J, Sriram D, Basavoju S
Mol Divers
. 2024 May;
29(1):303-317.
PMID: 38789853
A simple and effective three-component one-pot green methodology was employed for the synthesis of a new thiazolidine-2,4-dione based bisspirooxindolo-pyrrolidine derivatives using [Bmim]BF ionic liquid via [3 + 2] cycloaddition reaction....
6.
Mhetre U, Haval N, Bondle G, Rathod S, Choudhari P, Kumari J, et al.
Bioorg Med Chem Lett
. 2024 May;
108:129800.
PMID: 38763480
In a quest to discover new antimalarial and antitubercular drugs, we have designed and synthesized a series of novel triazole-quinazolinone hybrids. The in vitro screening of the triazole-quinazolinone hybrid entities...
7.
Dingis Birgul S, Kumari J, Tamhaev R, Mourey L, Lherbet C, Sriram D, et al.
J Biomol Struct Dyn
. 2024 Mar;
:1-19.
PMID: 38450660
Mycobacteria regulate the synthesis of mycolic acid through the fatty acid synthase system type 1 (FAS I) and the fatty acid synthase system type-2 (FAS-II). Because mammalian cells exclusively utilize...
8.
Purakkel U, Praveena G, Madabhushi V, Jadav S, Prakasham R, Dasugari Varakala S, et al.
ACS Omega
. 2024 Mar;
9(8):8846-8861.
PMID: 38434818
The rational design of novel thiazolo[2,3-][1,2,4]triazole derivatives was carried out based on previously identified antitubercular hit molecule H127 for discovering potent compounds showing antimicrobial activity. The designed compounds were screened...
9.
Chirra N, Abburi N, Rekha E, Pedapati R, Bollikanda R, Murahari M, et al.
Drug Dev Res
. 2024 Feb;
85(1):e22153.
PMID: 38349258
An innovative series of N-substituted piperazine-linked imidazothiazole derivatives 7(a-x) were synthesized, and their antitubercular effectiveness was evaluated. A three-step reaction sequence involving the condensation of 1,3-dichloroacetone and thiourea, coupling with...
10.
Kanchrana M, Gamidi R, Kumari J, Sriram D, Basavoju S
Mol Divers
. 2024 Jan;
28(6):3979-3991.
PMID: 38261121
The development of anti-tuberculosis (anti-TB) drugs has become a challenging task in medicinal chemistry. This is because Mycobacterium tuberculosis (TB), the pathogen that causes tuberculosis, has an increasing number of...