Derek M Murphy
Overview
Explore the profile of Derek M Murphy including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
375
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Recent Articles
1.
Murphy D, Castellanos-Rizaldos E, Makrigiorgos G
Clin Chem
. 2014 May;
60(7):1014-6.
PMID: 24799525
No abstract available.
2.
Lynch J, Fay J, Meehan M, Bryan K, Watters K, Murphy D, et al.
Carcinogenesis
. 2012 Mar;
33(5):976-85.
PMID: 22382496
Transforming growth factor-β (TGF-β) signaling regulates many diverse cellular activities through both canonical (SMAD-dependent) and non-canonical branches, which includes the mitogen-activated protein kinase (MAPK), Rho-like guanosine triphosphatase and phosphatidylinositol-3-kinase/AKT pathways....
3.
Murphy D, Buckley P, Das S, Watters K, Bryan K, Stallings R
PLoS One
. 2011 Jul;
6(6):e21436.
PMID: 21731748
Background: MYCN is a transcription factor that is expressed during the development of the neural crest and its dysregulation plays a major role in the pathogenesis of pediatric cancers such...
4.
Murphy D, Buckley P, Bryan K, Watters K, Koster J, van Sluis P, et al.
Mol Carcinog
. 2011 May;
50(6):403-11.
PMID: 21557326
Amplification of the oncogenic transcription factor MYCN plays a major role in the pathogenesis of several pediatric cancers, including neuroblastoma, medulloblastoma, and rhabodomyosarcoma. For neuroblastoma, MYCN amplification is the most...
5.
Das S, Foley N, Bryan K, Watters K, Bray I, Murphy D, et al.
Cancer Res
. 2010 Sep;
70(20):7874-81.
PMID: 20841484
Neuroblastoma is an often fatal pediatric cancer arising from precursor cells of the sympathetic nervous system. 13-Cis retinoic acid is included in the treatment regimen for patients with high-risk disease,...
6.
MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2
Foley N, Bray I, Tivnan A, Bryan K, Murphy D, Buckley P, et al.
Mol Cancer
. 2010 Apr;
9:83.
PMID: 20409325
Background: Neuroblastoma is a paediatric cancer of the sympathetic nervous system. The single most important genetic indicator of poor clinical outcome is amplification of the MYCN transcription factor. One of...
7.
Murphy D, Buckley P, Bryan K, Das S, Alcock L, Foley N, et al.
PLoS One
. 2009 Dec;
4(12):e8154.
PMID: 19997598
Background: Neuroblastoma, a cancer derived from precursor cells of the sympathetic nervous system, is a major cause of childhood cancer related deaths. The single most important prognostic indicator of poor...
8.
Bray I, Bryan K, Prenter S, Buckley P, Foley N, Murphy D, et al.
PLoS One
. 2009 Nov;
4(11):e7850.
PMID: 19924232
MiRNAs regulate gene expression at a post-transcriptional level and their dysregulation can play major roles in the pathogenesis of many different forms of cancer, including neuroblastoma, an often fatal paediatric...