Karen M Watters
Overview
Explore the profile of Karen M Watters including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
420
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0
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Recent Articles
1.
Kenny H, Hart P, Kordylewicz K, Lal M, Shen M, Kara B, et al.
Cancers (Basel)
. 2021 Aug;
13(16).
PMID: 34439084
The high mortality of OvCa is caused by the wide dissemination of cancer within the abdominal cavity. OvCa cells metastasize to the peritoneum, which is covered by mesothelial cells, and...
2.
Hart P, Kenny H, Grassl N, Watters K, Litchfield L, Coscia F, et al.
Cell Rep
. 2019 Dec;
29(12):4086-4098.e6.
PMID: 31851935
The tumor microenvironment (TME) plays a pivotal role in cancer progression, and, in ovarian cancer (OvCa), the primary TME is the omentum. Here, we show that the diabetes drug metformin...
3.
Watters K, Bajwa P, Kenny H
Cancers (Basel)
. 2018 Aug;
10(8).
PMID: 30096959
Ovarian cancer progression involves multifaceted and variable tumor microenvironments (TMEs), from the in situ carcinoma in the fallopian tube or ovary to dissemination into the peritoneal cavity as single cells...
4.
Bryan K, Terrile M, Bray I, Domingo-Fernandez R, Watters K, Koster J, et al.
Nucleic Acids Res
. 2013 Dec;
42(3):e17.
PMID: 24357407
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression at a post-transcriptional level. An miRNA may target many messenger RNA (mRNA) transcripts, and each transcript may be targeted...
5.
McCoy R, Widaa A, Watters K, Wuerstle M, Stallings R, Duffy G, et al.
Stem Cells
. 2013 Jul;
31(11):2420-31.
PMID: 23897668
Skeletogenesis is initiated during fetal development and persists through adult life as either a remodeling process in response to homeostatic regulation or as a regenerative process in response to physical...
6.
Watters K, Bryan K, Foley N, Meehan M, Stallings R
BMC Cancer
. 2013 Apr;
13:184.
PMID: 23565812
Background: Ultra-conserved regions (UCRs) are segments of the genome (≥ 200 bp) that exhibit 100% DNA sequence conservation between human, mouse and rat. Transcribed UCRs (T-UCRs) have been shown to...
7.
Lynch J, Fay J, Meehan M, Bryan K, Watters K, Murphy D, et al.
Carcinogenesis
. 2012 Mar;
33(5):976-85.
PMID: 22382496
Transforming growth factor-β (TGF-β) signaling regulates many diverse cellular activities through both canonical (SMAD-dependent) and non-canonical branches, which includes the mitogen-activated protein kinase (MAPK), Rho-like guanosine triphosphatase and phosphatidylinositol-3-kinase/AKT pathways....
8.
Murphy D, Buckley P, Das S, Watters K, Bryan K, Stallings R
PLoS One
. 2011 Jul;
6(6):e21436.
PMID: 21731748
Background: MYCN is a transcription factor that is expressed during the development of the neural crest and its dysregulation plays a major role in the pathogenesis of pediatric cancers such...
9.
Murphy D, Buckley P, Bryan K, Watters K, Koster J, van Sluis P, et al.
Mol Carcinog
. 2011 May;
50(6):403-11.
PMID: 21557326
Amplification of the oncogenic transcription factor MYCN plays a major role in the pathogenesis of several pediatric cancers, including neuroblastoma, medulloblastoma, and rhabodomyosarcoma. For neuroblastoma, MYCN amplification is the most...
10.
Bray I, Tivnan A, Bryan K, Foley N, Watters K, Tracey L, et al.
Cancer Lett
. 2011 Feb;
303(1):56-64.
PMID: 21310526
Several studies have implicated the dysregulation of microRNAs in neuroblastoma pathogenesis, an often fatal paediatric cancer arising from precursor cells of the sympathetic nervous system. Our group and others have...