Dennis L Wright
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Explore the profile of Dennis L Wright including associated specialties, affiliations and a list of published articles.
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83
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1033
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Recent Articles
1.
Ozcan Tezgin D, Kurkcu S, Si D, Krucinska J, Mosley A, Mehta P, et al.
Biochem Pharmacol
. 2024 Nov;
230(Pt 3):116617.
PMID: 39528074
Cellular resistance can limit the effectiveness of antifolate drugs for the treatment of cancer and autoimmune diseases. We examined the biochemical and cellular effects of a propargyl linked, non-classical antifolate...
2.
Bleiler M, Cyr A, Wright D, Giardina C
J Cell Sci
. 2023 Jan;
136(1).
PMID: 36606487
53BP1 (also known as TP53BP1) is a key mediator of the non-homologous end joining (NHEJ) DNA repair pathway, which is the primary repair pathway in interphase cells. However, the mitotic...
3.
Wright L, Wright D, Weller S
Viruses
. 2022 Jul;
14(7).
PMID: 35891537
In this review, we explore recombination in two very different virus families that have become major threats to human health. The Herpesviridae are a large family of pathogenic double-stranded DNA...
4.
Krucinska J, Lombardo M, Erlandsen H, Estrada A, Si D, Viswanathan K, et al.
Commun Biol
. 2022 May;
5(1):459.
PMID: 35562546
Two plasmid-encoded dihydrofolate reductase (DHFR) isoforms, DfrA1 and DfrA5, that give rise to high levels of resistance in Gram-negative bacteria were structurally and biochemically characterized to reveal the mechanism of...
5.
Wang S, Reeve S, Holt G, Ojewole A, Frenkel M, Gainza P, et al.
PLoS Comput Biol
. 2022 Feb;
18(2):e1009855.
PMID: 35143481
Antimicrobial resistance presents a significant health care crisis. The mutation F98Y in Staphylococcus aureus dihydrofolate reductase (SaDHFR) confers resistance to the clinically important antifolate trimethoprim (TMP). Propargyl-linked antifolates (PLAs), next...
6.
DiScipio K, Weerasooriya S, Szczepaniak R, Hazeen A, Wright L, Wright D, et al.
mBio
. 2022 Jan;
13(1):e0322621.
PMID: 35073739
The majority of drug discovery efforts against herpesviruses have focused on nucleoside analogs that target viral DNA polymerases, agents that are associated with dose-limiting toxicity and/or a narrow spectrum of...
7.
Medved J, Wood W, van Heyst M, Sherafat A, Song J, Sakya S, et al.
Glia
. 2020 Oct;
69(3):792-811.
PMID: 33098183
Oligodendrocyte precursor cells (OPCs), also known as NG2 cells or polydendrocytes, are distributed widely throughout the developing and mature central nervous system. They remain proliferative throughout life and are an...
8.
Krucinska J, Lombardo M, Erlandsen H, Hazeen A, Duay S, Pattis J, et al.
Sci Rep
. 2019 Nov;
9(1):17106.
PMID: 31745118
Many years ago, the natural secondary metabolite SF2312, produced by the actinomycete Micromonospora, was reported to display broad spectrum antibacterial properties against both Gram-positive and Gram-negative bacteria. Recent studies have...
9.
Reeve S, Si D, Krucinska J, Yan Y, Viswanathan K, Wang S, et al.
ACS Infect Dis
. 2019 Oct;
5(11):1896-1906.
PMID: 31565920
The spread of plasmid borne resistance enzymes in clinical isolates is rendering trimethoprim and iclaprim, both inhibitors of dihydrofolate reductase (DHFR), ineffective. Continued exploitation of these targets will require compounds...
10.
Krucinska J, Falcone E, Erlandsen H, Hazeen A, Lombardo M, Estrada A, et al.
Biochemistry
. 2019 Feb;
58(9):1188-1197.
PMID: 30714720
Enolase is a glycolytic metalloenzyme involved in carbon metabolism. The advantage of targeting enolase lies in its essentiality in many biological processes such as cell wall formation and RNA turnover...