Narendran G-Dayanandan
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Explore the profile of Narendran G-Dayanandan including associated specialties, affiliations and a list of published articles.
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11
Citations
114
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Recent Articles
1.
Gutierrez-Perez C, Puerner C, Jones J, Vellanki S, Vesely E, Xatse M, et al.
mBio
. 2024 Jun;
15(7):e0116624.
PMID: 38934618
Contemporary antifungal therapies utilized to treat filamentous fungal infections are inhibited by intrinsic and emerging drug resistance. Consequently, there is an urgent need to develop novel antifungal compounds that are...
2.
Parsons A, Ophir S, Gardner T, Paredes J, Stein K, Kwasny S, et al.
Antiviral Res
. 2022 Dec;
209:105474.
PMID: 36511318
Human cytomegalovirus (CMV) is a ubiquitous β-herpesvirus that establishes latent asymptomatic infections in healthy individuals but can cause serious infections in immunocompromised people, resulting in increased risk of morbidity and...
3.
Hajian B, Scocchera E, Shoen C, Krucinska J, Viswanathan K, G-Dayanandan N, et al.
Cell Chem Biol
. 2019 Apr;
26(6):781-791.e6.
PMID: 30930162
The folate biosynthetic pathway offers many druggable targets that have yet to be exploited in tuberculosis therapy. Herein, we have identified a series of small molecules that interrupt Mycobacterium tuberculosis...
4.
Haney S, Varney M, Safranek H, Chhonker Y, G-Dayanandan N, Talmon G, et al.
Leuk Res
. 2019 Jan;
77:17-27.
PMID: 30612055
Tropolones are naturally occurring seven-membered non-benzenoid aromatic compounds that are of interest due to their cytotoxic properties. MO-OH-Nap is a novel α-substituted tropolone that induces caspase cleavage and upregulates markers...
5.
G-Dayanandan N, Scocchera E, Keshipeddy S, Jones H, Anderson A, Wright D
Org Lett
. 2016 Dec;
19(1):142-145.
PMID: 27959567
To develop next generation antifolates for the treatment of trimethoprim-resistant bacteria, synthetic methods were needed to prepare a diverse array of 3-aryl-propynes with various substitutions at the propargyl position. A...
6.
Lombardo M, G-Dayanandan N, Wright D, Anderson A
ACS Infect Dis
. 2016 Sep;
2(2):149-56.
PMID: 27624966
Multidrug-resistant Enterobacteriaceae, notably Escherichia coli and Klebsiella pneumoniae, have become major health concerns worldwide. Resistance to effective therapeutics is often carried by class I and II integrons that can confer...
7.
Hajian B, Scocchera E, Keshipeddy S, G-Dayanandan N, Shoen C, Krucinska J, et al.
PLoS One
. 2016 Sep;
11(8):e0161740.
PMID: 27580226
Mycobacterium tuberculosis continues to cause widespread, life-threatening disease. In the last decade, this threat has grown dramatically as multi- and extensively-drug resistant (MDR and XDR) bacteria have spread globally and...
8.
Reeve S, Scocchera E, Ferreira J, G-Dayanandan N, Keshipeddy S, Wright D, et al.
J Med Chem
. 2016 Jun;
59(13):6493-500.
PMID: 27308944
Drug-resistant enzymes must balance catalytic function with inhibitor destabilization to provide a fitness advantage. This sensitive balance, often involving very subtle structural changes, must be achieved through a selection process...
9.
G-Dayanandan N, Paulsen J, Viswanathan K, Keshipeddy S, Lombardo M, Zhou W, et al.
J Med Chem
. 2014 Feb;
57(6):2643-56.
PMID: 24568657
Species of Candida, primarily C. albicans and with increasing prevalence, C. glabrata, are responsible for the majority of fungal bloodstream infections that cause morbidity, especially among immune compromised patients. While...
10.
Lamb K, G-Dayanandan N, Wright D, Anderson A
Biochemistry
. 2013 Sep;
52(41):7318-26.
PMID: 24053334
The pursuit of antimicrobial drugs that target dihydrofolate reductase (DHFR) exploits differences in sequence and dynamics between the pathogenic and human enzymes. Here, we present five crystal structures of human...