Dennis A Dougherty
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Explore the profile of Dennis A Dougherty including associated specialties, affiliations and a list of published articles.
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128
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3850
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Recent Articles
1.
Nichols A, Marotta C, Lukas H, Friesenhahn N, Wagenaar D, Mayo S, et al.
Nicotine Tob Res
. 2025 Mar;
PMID: 40079271
A minimally invasive "continuous nicotine monitor" (CNM) would resolve the dynamic nicotine concentration, [nicotine]t, faced by high-sensitivity nicotinic acetylcholine receptors (nAChRs) during and after nicotine intake by individual subjects. Motivations:...
2.
Dougherty D
Chem Rev
. 2025 Feb;
125(5):2793-2808.
PMID: 39977669
The cation-π interaction is an important noncovalent binding force that impacts all areas of chemistry and biology. Extensive computational and gas phase experimental studies have established the potential strength and...
3.
Haloi N, Huang S, Nichols A, Fine E, Friesenhahn N, Marotta C, et al.
Protein Eng Des Sel
. 2024 Feb;
37.
PMID: 38302088
We developed fluorescent protein sensors for nicotine with improved sensitivity. For iNicSnFR12 at pH 7.4, the proportionality constant for ∆F/F0vs [nicotine] (δ-slope, 2.7 μM-1) is 6.1-fold higher than the previously...
4.
Walker N, Yan Y, Tapia M, Tucker B, Thomas L, George B, et al.
eNeuro
. 2023 May;
10(5).
PMID: 37193602
Mesolimbic nicotinic acetylcholine receptor (nAChRs) activation is necessary for nicotine reinforcement behavior, but it is unknown whether selective activation of nAChRs in the dopamine (DA) reward pathway is sufficient to...
5.
Maldifassi M, Rego Campello H, Gallagher T, Lester H, Dougherty D
Mol Pharmacol
. 2023 Mar;
103(6):339-347.
PMID: 37001996
Study of 64 nicotinic acetylcholine receptors (nAChRs) as a pharmacological target has recently gained interest because of their involvement in analgesia, control of catecholamine secretion, dopaminergic pathways, and aversive pathways....
6.
Nichols A, Blumenfeld Z, Luebbert L, Knox H, Muthusamy A, Marvin J, et al.
J Neurosci
. 2023 Mar;
43(13):2222-2241.
PMID: 36868853
Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed treatment for individuals experiencing major depressive disorder. The therapeutic mechanisms that take place before, during, or after SSRIs bind the serotonin...
7.
Haloi N, Huang S, Nichols A, Fine E, Friesenhahn N, Marotta C, et al.
bioRxiv
. 2023 Jan;
PMID: 36712031
We developed fluorescent protein sensors for nicotine with improved sensitivity. For iNicSnFR12 at pH 7.4, the proportionality constant for vs [nicotine] (δ-slope, 2.7 μM) is 6.1-fold higher than the previously...
8.
Beatty Z, Muthusamy A, Unger E, Dougherty D, Tian L, Looger L, et al.
Bio Protoc
. 2022 Dec;
12(22).
PMID: 36532688
Subcellular pharmacokinetic measurements have informed the study of central nervous system (CNS)-acting drug mechanisms. Recent investigations have been enhanced by the use of genetically encoded fluorescent biosensors for drugs of...
9.
Nichols A, Blumenfeld Z, Fan C, Luebbert L, Blom A, Cohen B, et al.
Elife
. 2022 Dec;
11.
PMID: 36520038
No abstract available.
10.
Lummis S, Dougherty D
Membranes (Basel)
. 2022 Oct;
12(10).
PMID: 36295771
Pentameric ligand-gated ion channels (pLGIC) play important roles in fast neuronal signal transmission. Functional receptors are pentamers, with each subunit having an extracellular domain (ECD), a transmembrane domain (TMD) and...