Dennis A Dougherty
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Explore the profile of Dennis A Dougherty including associated specialties, affiliations and a list of published articles.
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128
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3850
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Recent Articles
11.
Knox H, Rego Campello H, Lester H, Gallagher T, Dougherty D
J Am Chem Soc
. 2022 Aug;
144(35):16101-16117.
PMID: 36006801
Nicotinic acetylcholine receptors (nAChRs) play an important role in neurotransmission and are also involved in addiction and several disease states. There is significant interest in therapeutic targeting of nAChRs; however,...
12.
Mocatta J, Mesoy S, Dougherty D, Lummis S
ACS Chem Neurosci
. 2022 Jul;
13(15):2338-2345.
PMID: 35867037
5-HT receptors are members of the family of pentameric ligand-gated ion channels. Each subunit has an extracellular, transmembrane, and intracellular domain. Only part of the intracellular domain structure has been...
13.
Muthusamy A, Kim C, Virgil S, Knox H, Marvin J, Nichols A, et al.
J Am Chem Soc
. 2022 Apr;
144(19):8480-8486.
PMID: 35446570
We report a reagentless, intensity-based S-methadone fluorescent sensor, iS-methadoneSnFR, consisting of a circularly permuted GFP inserted within the sequence of a mutated bacterial periplasmic binding protein (PBP). We evolved a...
14.
Nichols A, Blumenfeld Z, Fan C, Luebbert L, Blom A, Cohen B, et al.
Elife
. 2022 Jan;
11.
PMID: 34982029
Nicotinic partial agonists provide an accepted aid for smoking cessation and thus contribute to decreasing tobacco-related disease. Improved drugs constitute a continued area of study. However, there remains no reductionist...
15.
Blom A, Su J, Repka L, Reisman S, Dougherty D
ACS Med Chem Lett
. 2020 Nov;
11(11):2204-2211.
PMID: 33214830
γ-Aminobutyric acid type A (GABA) receptors are key mediators of central inhibitory neurotransmission and have been implicated in several disorders of the central nervous system. Some positive allosteric modulators (PAMs)...
16.
Baker B, Dougherty D, Lummis S
ACS Chem Neurosci
. 2020 Nov;
11(24):4215-4222.
PMID: 33201686
GABA receptors are homomeric pentameric ligand-gated ion channels (pLGICs) and are useful for probing the molecular details of the mechanism of action in this important protein family. Here, we explore...
17.
Lester H, Dougherty D
Neuron
. 2019 Nov;
104(3):431-432.
PMID: 31697916
In this issue of Neuron, Gharpure et al. (2019) nearly complete atomic-level descriptions for binding, permeation, and subunit interactions at the two major heteropentameric nicotinic receptors-those governing nicotine's rewarding and...
18.
Blom A, Rego Campello H, Lester H, Gallagher T, Dougherty D
J Am Chem Soc
. 2019 Sep;
141(40):15840-15849.
PMID: 31518499
Nicotinic acetylcholine receptors (nAChRs) are crucial for communication between synapses in the central nervous system. As such, they are also implicated in several neuropsychiatric and addictive diseases. Cytisine is a...
19.
Mosesso R, Dougherty D, Lummis S
ACS Chem Neurosci
. 2019 Jul;
10(7):3327-3333.
PMID: 31273982
Cys-loop receptors are important drug targets that are involved in signaling in the nervous system. The binding of neurotransmitters in the extracellular region of these receptors triggers an allosteric activation...
20.
Blunt C, Dougherty D
Mol Pharmacol
. 2019 Jun;
96(2):212-218.
PMID: 31175182
The 7 nicotinic acetylcholine receptor (nAChR) is a potential drug target for the treatment of a number of neurologic and inflammatory disorders. Silent agonists are an emerging class of drugs...