Aaron L Nichols
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Explore the profile of Aaron L Nichols including associated specialties, affiliations and a list of published articles.
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Citations
73
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Recent Articles
1.
Nichols A, Marotta C, Lukas H, Friesenhahn N, Wagenaar D, Mayo S, et al.
Nicotine Tob Res
. 2025 Mar;
PMID: 40079271
A minimally invasive "continuous nicotine monitor" (CNM) would resolve the dynamic nicotine concentration, [nicotine]t, faced by high-sensitivity nicotinic acetylcholine receptors (nAChRs) during and after nicotine intake by individual subjects. Motivations:...
2.
Haloi N, Huang S, Nichols A, Fine E, Friesenhahn N, Marotta C, et al.
Protein Eng Des Sel
. 2024 Feb;
37.
PMID: 38302088
We developed fluorescent protein sensors for nicotine with improved sensitivity. For iNicSnFR12 at pH 7.4, the proportionality constant for ∆F/F0vs [nicotine] (δ-slope, 2.7 μM-1) is 6.1-fold higher than the previously...
3.
Nichols A, Blumenfeld Z, Luebbert L, Knox H, Muthusamy A, Marvin J, et al.
J Neurosci
. 2023 Mar;
43(13):2222-2241.
PMID: 36868853
Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed treatment for individuals experiencing major depressive disorder. The therapeutic mechanisms that take place before, during, or after SSRIs bind the serotonin...
4.
Haloi N, Huang S, Nichols A, Fine E, Friesenhahn N, Marotta C, et al.
bioRxiv
. 2023 Jan;
PMID: 36712031
We developed fluorescent protein sensors for nicotine with improved sensitivity. For iNicSnFR12 at pH 7.4, the proportionality constant for vs [nicotine] (δ-slope, 2.7 μM) is 6.1-fold higher than the previously...
5.
Beatty Z, Muthusamy A, Unger E, Dougherty D, Tian L, Looger L, et al.
Bio Protoc
. 2022 Dec;
12(22).
PMID: 36532688
Subcellular pharmacokinetic measurements have informed the study of central nervous system (CNS)-acting drug mechanisms. Recent investigations have been enhanced by the use of genetically encoded fluorescent biosensors for drugs of...
6.
Nichols A, Blumenfeld Z, Fan C, Luebbert L, Blom A, Cohen B, et al.
Elife
. 2022 Dec;
11.
PMID: 36520038
No abstract available.
7.
Muthusamy A, Kim C, Virgil S, Knox H, Marvin J, Nichols A, et al.
J Am Chem Soc
. 2022 Apr;
144(19):8480-8486.
PMID: 35446570
We report a reagentless, intensity-based S-methadone fluorescent sensor, iS-methadoneSnFR, consisting of a circularly permuted GFP inserted within the sequence of a mutated bacterial periplasmic binding protein (PBP). We evolved a...
8.
Nichols A, Blumenfeld Z, Fan C, Luebbert L, Blom A, Cohen B, et al.
Elife
. 2022 Jan;
11.
PMID: 34982029
Nicotinic partial agonists provide an accepted aid for smoking cessation and thus contribute to decreasing tobacco-related disease. Improved drugs constitute a continued area of study. However, there remains no reductionist...
9.
Bera K, Kamajaya A, Shivange A, Muthusamy A, Nichols A, Borden P, et al.
Front Cell Neurosci
. 2019 Dec;
13:499.
PMID: 31798415
The target for the "rapid" (<24 h) antidepressant effects of S-ketamine is unknown, vitiating programs to rationally develop more effective rapid antidepressants. To describe a drug's target, one must first...
10.
Shivange A, Borden P, Muthusamy A, Nichols A, Bera K, Bao H, et al.
J Gen Physiol
. 2019 Feb;
151(6):738-757.
PMID: 30718376
Nicotine dependence is thought to arise in part because nicotine permeates into the endoplasmic reticulum (ER), where it binds to nicotinic receptors (nAChRs) and begins an "inside-out" pathway that leads...