Darren L Beene
Overview
Explore the profile of Darren L Beene including associated specialties, affiliations and a list of published articles.
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7
Citations
521
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Recent Articles
1.
Lummis S, Harrison N, Wang J, Ashby J, Millen K, Beene D, et al.
ACS Chem Neurosci
. 2012 Mar;
3(3):186-192.
PMID: 22448304
The ligand binding site of Cys-loop receptors is dominated by aromatic amino acids. In GABA(C) receptors, these are predominantly tyrosine residues, with a number of other aromatic residues located in...
2.
Beene D, Scott J
Curr Opin Cell Biol
. 2007 Feb;
19(2):192-8.
PMID: 17317140
A-kinase anchoring proteins (AKAPs) are signaling scaffolds that contribute to various aspects of cAMP signaling. They do this by tethering protein kinase-A to specific subcellular sites, thereby focusing its activity...
3.
Lummis S, Beene D, Lee L, Lester H, Broadhurst R, Dougherty D
Nature
. 2005 Nov;
438(7065):248-52.
PMID: 16281040
5-hydroxytryptamine type 3 (5-HT3) receptors are members of the Cys-loop receptor superfamily. Neurotransmitter binding in these proteins triggers the opening (gating) of an ion channel by means of an as-yet-uncharacterized...
4.
Lummis S, Beene D, Harrison N, Lester H, Dougherty D
Chem Biol
. 2005 Sep;
12(9):993-7.
PMID: 16183023
GABA(C) (rho) receptors are members of the Cys-loop superfamily of neurotransmitter receptors, which includes nicotinic acetylcholine (nACh), 5-HT(3), and glycine receptors. As in other members of this family, the agonist...
5.
Beene D, Price K, Lester H, Dougherty D, Lummis S
J Neurosci
. 2004 Oct;
24(41):9097-104.
PMID: 15483128
The mechanism by which agonist binding triggers pore opening in ligand-gated ion channels is poorly understood. Here, we used unnatural amino acid mutagenesis to introduce subtle changes to the side...
6.
Beene D, Dougherty D, Lester H
Curr Opin Neurobiol
. 2003 Jul;
13(3):264-70.
PMID: 12850209
Unnatural amino acid mutagenesis makes possible the site-specific incorporation of synthetic amino acids, enabling detailed structure-function studies as well as the incorporation of biophysical probes. This method has been adapted...
7.
Beene D, Brandt G, Zhong W, Zacharias N, Lester H, Dougherty D
Biochemistry
. 2002 Aug;
41(32):10262-9.
PMID: 12162741
A series of tryptophan analogues has been introduced into the binding site regions of two ion channels, the ligand-gated nicotinic acetylcholine and serotonin 5-HT(3A) receptors, using unnatural amino acid mutagenesis...