Denis Seraphin
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Explore the profile of Denis Seraphin including associated specialties, affiliations and a list of published articles.
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39
Citations
231
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Recent Articles
1.
Cerqua I, Neukirch K, Terlizzi M, Granato E, Caiazzo E, Cicala C, et al.
Pharmacol Res
. 2022 May;
181:106250.
PMID: 35562015
Benefits for vitamin E intake in diseases with inflammatory components have been described and related in part, to endogenously formed metabolites (long-chain metabolites, LCM). Here, we have evaluated the role...
2.
Moller G, Temml V, Cala Peralta A, Gruet O, Richomme P, Seraphin D, et al.
Metabolites
. 2022 Feb;
12(2).
PMID: 35208174
Naturally occurring substances are valuable resources for drug development. In this respect, chalcones are known to be antiproliferative agents against prostate cancer cell lines through various mechanisms or targets. Based...
3.
Kretzer C, Jordan P, Meyer K, Hoff D, Werner M, Hofstetter R, et al.
Biochem Pharmacol
. 2021 Nov;
195:114825.
PMID: 34762841
Specialized pro-resolving mediators (SPMs) comprise lipid mediators (LMs) produced from polyunsaturated fatty acids (PUFAs) via stereoselective oxygenation particularly involving 12/15-lipoxygenases (LOXs). In contrast to pro-inflammatory LMs such as leukotrienes formed...
4.
Neukirch K, Alsabil K, Dinh C, Bilancia R, Raasch M, Ville A, et al.
J Med Chem
. 2021 Jul;
64(15):11496-11526.
PMID: 34279935
Endogenous long-chain metabolites of vitamin E (LCMs) mediate immune functions by targeting 5-lipoxygenase (5-LOX) and increasing the systemic concentrations of resolvin E3, a specialized proresolving lipid mediator. SAR studies on...
5.
Viault G, Kempf M, Ville A, Alsabil K, Perrot R, Richomme P, et al.
ChemMedChem
. 2020 Nov;
16(5):881-890.
PMID: 33219748
New 5-substituted vitamin E derivatives were semisynthesized, and their antibacterial activity against human Gram-positive and Gram-negative pathogens was evaluated. Several vitamin E analogues were active against methicillin-resistant Staphylococcus aureus (MRSA)...
6.
Dinh C, Ville A, Neukirch K, Viault G, Temml V, Koeberle A, et al.
Eur J Med Chem
. 2020 Jul;
202:112518.
PMID: 32668380
Inflammation contributes to the development of various pathologies, e.g. asthma, cardiovascular diseases, some types of cancer, and metabolic disorders. Leukotrienes (LT), biosynthesized from arachidonic acid by 5-lipoxygenase (5-LO), constitute a...
7.
Ville A, Viault G, Helesbeux J, Guilet D, Richomme P, Seraphin D
J Nat Prod
. 2019 Jan;
82(1):51-58.
PMID: 30629440
Recent studies have highlighted the biological potential of tocotrienols, a vitamin E subfamily. The major natural sources of tocotrienols are complex mixtures requiring particularly challenging purification processes. The present study...
8.
Mezache N, Derbre S, Laouer H, Richomme P, Seraphin D, Akkal S
Nat Prod Res
. 2018 Oct;
33(15):2182-2191.
PMID: 30375240
Alkaloids and phenolic compounds are among the most biologically active natural products from the / genera (Asteraceae). To isolate original natural products directly from crude polar extracts, centrifugal partition chromatography...
9.
Schinkovitz A, Le Pogam P, Derbre S, Roy-Vessieres E, Blanchard P, Thirumaran S, et al.
Fitoterapia
. 2018 Oct;
131:182-188.
PMID: 30339926
Secondary metabolites from lichens are known for exhibiting various biological effects such as anti-inflammatory, antioxidant and antibacterial activities. Despite this wide range of reported biological effects, their impact on the...
10.
Pein H, Ville A, Pace S, Temml V, Garscha U, Raasch M, et al.
Nat Commun
. 2018 Sep;
9(1):3834.
PMID: 30237488
Systemic vitamin E metabolites have been proposed as signaling molecules, but their physiological role is unknown. Here we show, by library screening of potential human vitamin E metabolites, that long-chain...