Debra Mitchell
Overview
Explore the profile of Debra Mitchell including associated specialties, affiliations and a list of published articles.
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29
Citations
774
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Recent Articles
1.
Pu D, Mitchell D, Brusco N, Stephen K, Hutchinson A, Griffith A, et al.
PLoS One
. 2024 Dec;
19(12):e0314956.
PMID: 39671381
The research-to-practice gap is a well-known phenomenon. The adoption of evidence into clinical practice needs to consider the complexity of the health care system and a multitude of contextual issues....
2.
Mitchell D, Maloney S, Robinson L, Haines T, Foo J
Med Educ
. 2024 Oct;
59(4):368-381.
PMID: 39479876
Purpose: Student-led clinics generate a range of benefits to multiple stakeholder groups. Students receive important educational opportunities to advance in their training. Patients with limited access to care may access...
3.
Mertz T, Rice-Reynolds E, Nguyen L, Wood A, Cordero C, Bray N, et al.
Genome Res
. 2023 Aug;
33(9):1568-1581.
PMID: 37532520
The cytidine deaminases APOBEC3A (A3A) and APOBEC3B (A3B) are prominent mutators of human cancer genomes. However, tumor-specific genetic modulators of APOBEC-induced mutagenesis are poorly defined. Here, we used a screen...
4.
Laughery M, Plummer D, Wilson H, Vandenberg B, Mitchell D, Mieczkowski P, et al.
Genetics
. 2023 May;
224(3).
PMID: 37170598
Ultraviolet (UV) light primarily causes C > T substitutions in lesion-forming dipyrimidine sequences. However, many of the key driver mutations in melanoma do not fit this canonical UV signature, but...
5.
Vandenberg B, Laughery M, Cordero C, Plummer D, Mitchell D, Kreyenhagen J, et al.
Nat Commun
. 2023 May;
14(1):2576.
PMID: 37142570
UV exposure induces a mutation signature of C > T substitutions at dipyrimidines in skin cancers. We recently identified additional UV-induced AC > TT and A > T substitutions that...
6.
Mertz T, Rice-Reynolds E, Nguyen L, Wood A, Bray N, Mitchell D, et al.
bioRxiv
. 2023 Apr;
PMID: 37066362
The cytidine deaminases APOBEC3A and APOBEC3B (A3B) are prominent mutators of human cancer genomes. However, tumor-specific genetic modulators of APOBEC-induced mutagenesis are poorly defined. Here, we utilized a screen to...
7.
Haines T, Botti M, Brusco N, OBrien L, Redley B, Bowles K, et al.
PLoS One
. 2021 Dec;
16(12):e0261793.
PMID: 34969050
Disinvestment is the removal or reduction of previously provided practices or services, and has typically been undertaken where a practice or service has been clearly shown to be ineffective, inefficient...
8.
Bonilla B, Brown A, Hengel S, Rapchak K, Mitchell D, Pressimone C, et al.
Elife
. 2021 Nov;
10.
PMID: 34723799
Three-methyl cytosine (3meC) are toxic DNA lesions, blocking base pairing. Bacteria and humans express members of the AlkB enzymes family, which directly remove 3meC. However, other organisms, including budding yeast,...
9.
Laughery M, Brown A, Bohm K, Sivapragasam S, Morris H, Tchmola M, et al.
Cell Rep
. 2020 Nov;
33(7):108401.
PMID: 33207206
Somatic mutations in skin cancers and other ultraviolet (UV)-exposed cells are typified by C>T and CC>TT substitutions at dipyrimidine sequences; however, many oncogenic "driver" mutations in melanoma do not fit...
10.
Cortez L, Brown A, Dennis M, Collins C, Brown A, Mitchell D, et al.
PLoS Genet
. 2019 Dec;
15(12):e1008545.
PMID: 31841499
APOBEC cytidine deaminases are the second-most prominent source of mutagenesis in sequenced tumors. Previous studies have proposed that APOBEC3B (A3B) is the major source of mutagenesis in breast cancer (BRCA)....