David W Griggs
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Explore the profile of David W Griggs including associated specialties, affiliations and a list of published articles.
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31
Citations
1236
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Recent Articles
1.
Ajiboye J, Teixeira J, Gasonoo M, Mattice E, Korwin-Mihavics B, Miller P, et al.
Nat Commun
. 2024 Sep;
15(1):8272.
PMID: 39333545
Cryptosporidium parvum and C. hominis are parasites that cause life-threatening diarrhea in children and immunocompromised people. There is only one approved treatment that is modestly effective for children and ineffective...
2.
Schubert T, Oboh E, Peek H, Philo E, Teixeira J, Stebbins E, et al.
J Med Chem
. 2023 Jun;
66(12):7834-7848.
PMID: 37267631
Our previous work identified compound (SLU-2633) as a potent lead compound toward the identification of a novel treatment for cryptosporidiosis, caused by the parasite (EC = 0.17 μM). While this...
3.
West C, Tobo C, Au J, Johnson D, Mottaleb M, Robinson J, et al.
Am J Physiol Cell Physiol
. 2023 May;
324(6):C1341-C1352.
PMID: 37184231
Volumetric muscle loss (VML) causes irrecoverable loss of muscle mass and strength and results in permanent disability. VML injury shows extensive fibrosis, which impedes functional tissue regeneration. Our lab has...
4.
Scott N, Thirunavukkarasu S, Rangel-Moreno J, Griggs D, Khader S
J Interferon Cytokine Res
. 2022 Aug;
42(8):421-429.
PMID: 35914102
Tuberculosis (TB) caused by the pathogenic bacterium () is one of the most lethal infectious diseases in the world. Presently, Bacillus Calmette-Guerin, the vaccine approved for use against TB, does...
5.
Zangi M, Donald K, Gazquez Casals A, Franson A, Yu A, Marker E, et al.
Eur J Med Chem
. 2022 May;
238:114443.
PMID: 35635945
We previously showed that the anti-fungal drug ciclopirox olamine effectively inhibits replication of herpes simplex virus (HSV)-1 and HSV-2. Given the rise of HSV strains that are resistant to nucleos(t)ide...
6.
Oboh E, Schubert T, Teixeira J, Stebbins E, Miller P, Philo E, et al.
J Med Chem
. 2021 Aug;
64(15):11729-11745.
PMID: 34342443
Cryptosporidiosis is caused by infection of the small intestine by parasites, resulting in severe diarrhea, dehydration, malabsorption, and potentially death. The only FDA-approved therapeutic is only partially effective in young...
7.
Hasan M, Stebbins E, Choy R, Gillespie J, de Hostos E, Miller P, et al.
Antimicrob Agents Chemother
. 2021 Mar;
65(6).
PMID: 33753338
The intestinal protozoan is a leading cause of diarrheal disease and mortality in young children. There is currently no fully effective treatment for cryptosporidiosis, which has stimulated interest in anticryptosporidial...
8.
Hirai T, Yang Y, Zenke Y, Li H, Chaudhri V, De La Cruz Diaz J, et al.
Immunity
. 2020 Nov;
54(1):84-98.e5.
PMID: 33212014
Following antigen-driven expansion in lymph node, transforming growth factor-β (TGFβ) is required for differentiation of skin-recruited CD8 T cell effectors into epidermal resident memory T (Trm) cells and their epidermal...
9.
Basta J, Robbins L, Stout L, Prinsen M, Griggs D, Rauchman M
Physiol Rep
. 2020 Apr;
8(7):e14329.
PMID: 32281744
Fibrosis is a final common pathway for many causes of progressive chronic kidney disease (CKD). Arginine-glycine-aspartic acid (RGD)-binding integrins are important mediators of the pro-fibrotic response by activating latent TGF-β...
10.
Karpova D, Rettig M, Ritchey J, Cancilla D, Christ S, Gehrs L, et al.
J Clin Invest
. 2019 May;
129(7):2745-2759.
PMID: 31085833
Mobilized peripheral blood has become the primary source of hematopoietic stem and progenitor cells (HSPCs) for stem cell transplantation, with a five-day course of granulocyte colony stimulating factor (G-CSF) as...