David T Beattie
Overview
Explore the profile of David T Beattie including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
20
Citations
174
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Ullman J, Dick R, Linzner D, Minga T, Tep S, Satterfield T, et al.
Clin Pharmacol Ther
. 2024 Oct;
116(6):1580-1592.
PMID: 39439155
Pompe disease is a rare glycogen storage disease caused by mutations in the enzyme acid α-glucosidase (GAA) resulting in pathological accumulation of glycogen in muscle tissues leading to progressive weakness...
2.
Leippe D, Choy R, Vidugiris G, Merritt H, Mellem K, Beattie D, et al.
ACS Omega
. 2024 Aug;
9(30):33072-33080.
PMID: 39100309
Glycogen is a large polymer of glucose that functions as an important means of storing energy and maintaining glucose homeostasis. Glycogen synthesis and degradation pathways are highly regulated and their...
3.
Ullman J, Mellem K, Xi Y, Ramanan V, Merritt H, Choy R, et al.
Sci Transl Med
. 2024 Jan;
16(730):eadf1691.
PMID: 38232139
Glycogen synthase 1 (GYS1), the rate-limiting enzyme in muscle glycogen synthesis, plays a central role in energy homeostasis and has been proposed as a therapeutic target in multiple glycogen storage...
4.
Sandborn W, Nguyen D, Beattie D, Brassil P, Krey W, Woo J, et al.
J Crohns Colitis
. 2020 Mar;
14(9):1202-1213.
PMID: 32161949
Background And Aims: Oral systemic pan-Janus kinase [JAK] inhibition is effective for ulcerative colitis [UC] but is limited by toxicities. We describe preclinical to clinical translation of TD-1473-an oral gut-selective...
5.
Long D, Armstrong S, Beattie D, Campbell C, Church T, Colson P, et al.
ACS Med Chem Lett
. 2019 Dec;
10(12):1641-1647.
PMID: 31857840
The effects of opioids in the central nervous system (CNS) provide significant benefit in the treatment of pain but can also lead to physical dependence and addiction, which has contributed...
6.
Beattie D, Pulido-Rios M, Shen F, Ho M, Situ E, Tsuruda P, et al.
J Inflamm (Lond)
. 2017 Dec;
14:28.
PMID: 29225517
Background: An unmet need remains for safe and effective treatments to induce and maintain remission in inflammatory bowel disease (IBD) patients. The Janus kinase (JAK) inhibitor, tofacitinib, has demonstrated robust...
7.
Jiang L, Beattie D, Jacobsen J, Kintz S, Obedencio G, Saito D, et al.
Bioorg Med Chem Lett
. 2017 May;
27(13):2926-2930.
PMID: 28499731
Gastrointestinal dysfunction as a consequence of the use of opioid analgesics is of significant clinical concern. First generation drugs to treat these opioid-induced side-effects were limited by their negative impact...
8.
McKinnell R, Armstrong S, Beattie D, Fatheree P, Long D, Marquess D, et al.
Bioorg Med Chem Lett
. 2013 Jun;
23(14):4210-5.
PMID: 23756062
The discovery of a series of 5-HT4 receptor agonists based on a novel 2-alkylbenzimidazole aromatic core is described. Optimization of the 2-substituent of the benzimidazole ring led to a series...
9.
Tsuruda P, Vickery R, Long D, Armstrong S, Beattie D
Naunyn Schmiedebergs Arch Pharmacol
. 2013 Apr;
386(6):479-91.
PMID: 23549670
The clinical efficacy of opioid receptor antagonists for the treatment of opioid-induced constipation (OIC) is established. Peripherally selective antagonists are intended to provide OIC symptom relief without compromising the analgesic...
10.
Armstrong S, Campbell C, Richardson C, Vickery R, Tsuruda P, Long D, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 2013 Mar;
386(6):471-8.
PMID: 23512167
The in vivo preclinical pharmacodynamic profile of TD-1211, a selective opioid receptor antagonist currently under development for the treatment of opioid-induced constipation, was compared to that of the clinically studied...