Pamela R Tsuruda
Overview
Explore the profile of Pamela R Tsuruda including associated specialties, affiliations and a list of published articles.
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17
Citations
1869
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0
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Recent Articles
1.
Crespo-Garcia S, Fournier F, Diaz-Marin R, Klier S, Ragusa D, Masaki L, et al.
Nat Med
. 2024 Feb;
30(2):443-454.
PMID: 38321220
Compromised vascular endothelial barrier function is a salient feature of diabetic complications such as sight-threatening diabetic macular edema (DME). Current standards of care for DME manage aspects of the disease,...
2.
Crespo-Garcia S, Tsuruda P, Dejda A, Ryan R, Fournier F, Chaney S, et al.
Cell Metab
. 2021 Feb;
33(4):818-832.e7.
PMID: 33548171
Attenuating pathological angiogenesis in diseases characterized by neovascularization such as diabetic retinopathy has transformed standards of care. Yet little is known about the molecular signatures discriminating physiological blood vessels from...
3.
Long D, Armstrong S, Beattie D, Campbell C, Church T, Colson P, et al.
ACS Med Chem Lett
. 2019 Dec;
10(12):1641-1647.
PMID: 31857840
The effects of opioids in the central nervous system (CNS) provide significant benefit in the treatment of pain but can also lead to physical dependence and addiction, which has contributed...
4.
Shen F, Tsuruda P, Smith J, Obedencio G, Martin W
PLoS One
. 2013 Oct;
8(9):e74891.
PMID: 24098676
Multimodal analgesia is designed to optimize pain relief by coadministering drugs with distinct mechanisms of action or by combining multiple pharmacologies within a single molecule. In clinical settings, combinations of...
5.
Tsuruda P, Vickery R, Long D, Armstrong S, Beattie D
Naunyn Schmiedebergs Arch Pharmacol
. 2013 Apr;
386(6):479-91.
PMID: 23549670
The clinical efficacy of opioid receptor antagonists for the treatment of opioid-induced constipation (OIC) is established. Peripherally selective antagonists are intended to provide OIC symptom relief without compromising the analgesic...
6.
Armstrong S, Campbell C, Richardson C, Vickery R, Tsuruda P, Long D, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 2013 Mar;
386(6):471-8.
PMID: 23512167
The in vivo preclinical pharmacodynamic profile of TD-1211, a selective opioid receptor antagonist currently under development for the treatment of opioid-induced constipation, was compared to that of the clinically studied...
7.
Gerhold K, Pellegrino M, Tsunozaki M, Morita T, Leitch D, Tsuruda P, et al.
PLoS One
. 2013 Feb;
8(1):e55001.
PMID: 23383028
Little is known about the molecular mechanisms underlying mammalian touch transduction. To identify novel candidate transducers, we examined the molecular and cellular basis of touch in one of the most...
8.
Bourdet D, Tsuruda P, Obedencio G, Smith J
J Pharmacol Exp Ther
. 2012 Jan;
341(1):137-45.
PMID: 22235148
Translation of central nervous system occupancy and clinical effect from animal models to humans has remained elusive for many pharmacological targets. The current studies evaluate the ability of a rodent...
9.
Beattie D, Armstrong S, Vickery R, Tsuruda P, Campbell C, Richardson C, et al.
Front Pharmacol
. 2011 Jun;
2:25.
PMID: 21687517
This study evaluated the in vitro and in vivo pharmacological properties of TD-8954, a potent and selective 5-HT(4) receptor agonist. TD-8954 had high affinity (pK(i) = 9.4) for human recombinant...
10.
Shen F, Smith J, Chang R, Bourdet D, Tsuruda P, Obedencio G, et al.
Neuropharmacology
. 2011 Mar;
61(1-2):69-79.
PMID: 21392515
There remains an urgent need for therapeutic agents that provide improved symptomatic treatment and attenuate disease progression in patients with Alzheimer's disease (AD). 5-HT(4) receptors are widely expressed in those...