Paul R Fatheree
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Explore the profile of Paul R Fatheree including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
83
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Recent Articles
1.
McKinnell R, Armstrong S, Beattie D, Fatheree P, Long D, Marquess D, et al.
Bioorg Med Chem Lett
. 2013 Jun;
23(14):4210-5.
PMID: 23756062
The discovery of a series of 5-HT4 receptor agonists based on a novel 2-alkylbenzimidazole aromatic core is described. Optimization of the 2-substituent of the benzimidazole ring led to a series...
2.
Long D, Armstrong S, Beattie D, Choi S, Fatheree P, Gendron R, et al.
Bioorg Med Chem Lett
. 2012 Sep;
22(19):6048-52.
PMID: 22959244
Utilization of Theravance's multivalent approach to drug discovery towards 5-HT(4) receptor agonists with a focus on identification of neutral (non-charged at physiological pH) secondary binding groups is described. Optimization of...
3.
Long D, Armstrong S, Beattie D, Choi S, Fatheree P, Gendron R, et al.
Bioorg Med Chem Lett
. 2012 Jun;
22(14):4849-53.
PMID: 22683222
Further application of our multivalent approach to drug discovery directed to 5-HT(4) receptor agonists is described. Optimization of the linker and secondary binding amine in the indazole-tropane primary binding group...
4.
McKinnell R, Armstrong S, Beattie D, Choi S, Fatheree P, Gendron R, et al.
J Med Chem
. 2009 Aug;
52(17):5330-43.
PMID: 19663444
5-HT(4) receptor agonists such as tegaserod have demonstrated efficacy in the treatment of constipation predominant irritable bowel syndrome (IBS-C), a highly prevalent disorder characterized by chronic constipation and impairment of...
5.
Long D, Aggen J, Chinn J, Choi S, Christensen B, Fatheree P, et al.
J Antibiot (Tokyo)
. 2009 Jan;
61(10):603-14.
PMID: 19168974
Further investigations towards novel glycopeptide/beta-lactam heterodimers are reported. Employing a multivalent approach to drug discovery, vancomycin and cephalosporin synthons, 4, 2, 5 and 10, 18, 25 respectively, were chemically linked...
6.
Leadbetter M, Adams S, Bazzini B, Fatheree P, Karr D, Krause K, et al.
J Antibiot (Tokyo)
. 2004 Aug;
57(5):326-36.
PMID: 15303493
Novel derivatives of N-decylaminoethylvancomycin (2), containing appended hydrophilic groups were synthesized and their antibacterial activity and ADME properties were evaluated. The compounds were prepared by reacting amines with the C-terminus...