David Sabatino
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Explore the profile of David Sabatino including associated specialties, affiliations and a list of published articles.
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35
Citations
194
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Recent Articles
1.
Hilan G, Daniel G, Collak F, Sabatino D, Willmore W
J Pept Sci
. 2025 Feb;
31(3):e70007.
PMID: 39967318
This study investigated a peptide-based GRP78-targeting strategy for short-interfering (si) RNA delivery in cancer cells. Synthetic fluorescein-labeled amphiphilic peptides composed of the hydrophobic cell surface (cs) GRP78-targeting and hydrophilic, polycationic...
2.
Nissan N, Allen M, Sabatino D, Biggar K
Biomolecules
. 2024 Oct;
14(10).
PMID: 39456236
The expansive field of drug discovery is continually seeking innovative approaches to identify and develop novel peptide-based therapeutics. With the advent of artificial intelligence (AI), there has been a transformative...
3.
Daniel G, Hilan G, Ploeg L, Sabatino D
Bioorg Med Chem Lett
. 2024 Mar;
102:129682.
PMID: 38432287
Amphiphilic peptide sequences are conducive to secondary structures that self-assemble into higher-ordered peptide nanostructures. A select set of amphiphilic polycationic peptides displayed stable helical-coiled structures that self-assembled into peptide nanofibers....
4.
Sabatino D, Henneman A, Ahmad S, Jou E, Goldberg B
J Oncol Pharm Pract
. 2022 Mar;
29(4):840-845.
PMID: 35293248
Gemtuzumab ozogamicin (GO) and inotuzumab ozogamicin (InO) are indicated for newly diagnosed or relapsed/refractory CD33-positive acute myeloid leukemia and relapsed/refractory B-cell precursor acute lymphoblastic leukemia respectively. Patients undergoing therapy with...
5.
Sarkar B, Siddiqui Z, Nguyen P, Dube N, Fu W, Park S, et al.
ACS Biomater Sci Eng
. 2021 Jan;
5(9):4657-4670.
PMID: 33448838
Self-assembled peptide nanofibers can form biomimetic hydrogels at physiological pH and ionic strength through noncovalent and reversible interactions. Inspired by natural antimicrobial peptides, we designed a class of cationic amphiphilic...
6.
Sabatino D
J Med Chem
. 2020 Sep;
63(23):14184-14196.
PMID: 32990437
The evolution of rapidly proliferating infectious and tumorigenic diseases has resulted in an urgent need to develop new and improved intervention strategies. Among the many therapeutic strategies at our disposal,...
7.
Descalzi-Montoya D, Montel R, Smith K, Dziopa E, Darwich A, Yang Z, et al.
Chembiochem
. 2020 Sep;
22(9):1589-1596.
PMID: 32964656
De novo cancer-targeting immunostimulatory peptides have been designed and developed as synthetic antibody mimics. A series of bifunctional peptides incorporating NKp30-binding and NK-cell-activating domains were synthesized as linear dimers and...
8.
Proulx C, Zhang J, Sabatino D, Chemtob S, Ong H, Lubell W
Biomedicines
. 2020 Jul;
8(8).
PMID: 32717955
The innovative development of azapeptide analogues of growth hormone releasing peptide-6 (GHRP-6) has produced selective modulators of the cluster of differentiation 36 receptor (CD36). The azapeptide CD36 modulators curb macrophage-driven...
9.
Shah S, Casanova N, Antuono G, Sabatino D
Front Chem
. 2020 Apr;
8:218.
PMID: 32296681
Cell penetrating and targeting peptides (CPPs and CTPs) encompass an important class of biochemically active peptides owning the capabilities of targeting and translocating within selected cell types. As such, they...
10.
Shah S, Cultrara C, Ramos J, Samuni U, Zilberberg J, Sabatino D
J Mater Chem B
. 2020 Feb;
8(10):2169-2176.
PMID: 32096520
Nucleic acids templated on gold (Au) surfaces have led to a wide range of functional materials ranging from microarrays, sensors and probes in addition to drug delivery and treatment. In...