David R Critchley
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Explore the profile of David R Critchley including associated specialties, affiliations and a list of published articles.
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74
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5844
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Recent Articles
1.
Mathew S, Palamuttam R, Mernaugh G, Ramalingam H, Lu Z, Zhang M, et al.
Development
. 2017 Oct;
144(22):4148-4158.
PMID: 28993400
Kidney collecting system development requires integrin-dependent cell-extracellular matrix interactions. Integrins are heterodimeric transmembrane receptors consisting of α and β subunits; crucial integrins in the kidney collecting system express the β1...
2.
Manso A, Okada H, Sakamoto F, Moreno E, Monkley S, Li R, et al.
Proc Natl Acad Sci U S A
. 2017 Jul;
114(30):E6250-E6259.
PMID: 28698364
Continuous contraction-relaxation cycles of the heart require strong and stable connections of cardiac myocytes (CMs) with the extracellular matrix (ECM) to preserve sarcolemmal integrity. CM attachment to the ECM is...
3.
Zacharchenko T, Qian X, Goult B, Jethwa D, Almeida T, Ballestrem C, et al.
Structure
. 2016 Jun;
24(7):1130-41.
PMID: 27265849
Cell migration requires coordination between integrin-mediated cell adhesion to the extracellular matrix and force applied to adhesion sites. Talin plays a key role in coupling integrin receptors to the actomyosin...
4.
Atherton P, Stutchbury B, Wang D, Jethwa D, Tsang R, Meiler-Rodriguez E, et al.
Nat Commun
. 2015 Dec;
6:10038.
PMID: 26634421
The link between extracellular-matrix-bound integrins and intracellular F-actin is essential for cell spreading and migration. Here, we demonstrate how the actin-binding proteins talin and vinculin cooperate to provide this link....
5.
Liu J, Wang Y, Goh W, Goh H, Baird M, Ruehland S, et al.
Proc Natl Acad Sci U S A
. 2015 Aug;
112(35):E4864-73.
PMID: 26283369
Insight into how molecular machines perform their biological functions depends on knowledge of the spatial organization of the components, their connectivity, geometry, and organizational hierarchy. However, these parameters are difficult...
6.
Rainero E, Howe J, Caswell P, Jamieson N, Anderson K, Critchley D, et al.
Cell Rep
. 2015 Jan;
10(3):398-413.
PMID: 25600874
Integrin trafficking is key to cell migration, but little is known about the spatiotemporal organization of integrin endocytosis. Here, we show that α5β1 integrin undergoes tensin-dependent centripetal movement from the...
7.
Tian X, Kim J, Monkley S, Gotoh N, Nandez R, Soda K, et al.
J Clin Invest
. 2014 Feb;
124(3):1098-113.
PMID: 24531545
Podocytes are specialized actin-rich epithelial cells that line the kidney glomerular filtration barrier. The interface between the podocyte and the glomerular basement membrane requires integrins, and defects in either α3...
8.
Calderwood D, Campbell I, Critchley D
Nat Rev Mol Cell Biol
. 2013 Jul;
14(8):503-17.
PMID: 23860236
Integrin receptors provide a dynamic, tightly-regulated link between the extracellular matrix (or cellular counter-receptors) and intracellular cytoskeletal and signalling networks, enabling cells to sense and respond to their chemical and...
9.
Goult B, Xu X, Gingras A, Swift M, Patel B, Bate N, et al.
J Struct Biol
. 2013 Jun;
184(1):21-32.
PMID: 23726984
Talin is a large adaptor protein that activates integrins and couples them to cytoskeletal actin. Talin contains an N-terminal FERM (band 4.1, ezrin, radixin, moesin) domain (the head) linked to...
10.
Goult B, Zacharchenko T, Bate N, Tsang R, Hey F, Gingras A, et al.
J Biol Chem
. 2013 Feb;
288(12):8238-8249.
PMID: 23389036
Talin activates integrins, couples them to F-actin, and recruits vinculin to focal adhesions (FAs). Here, we report the structural characterization of the talin rod: 13 helical bundles (R1-R13) organized into...