David R Critchley
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Explore the profile of David R Critchley including associated specialties, affiliations and a list of published articles.
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74
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5844
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Recent Articles
11.
Manso A, Li R, Monkley S, Cruz N, Ong S, Lao D, et al.
J Biol Chem
. 2012 Dec;
288(6):4252-64.
PMID: 23266827
Integrins are adhesive, signaling, and mechanotransduction proteins. Talin (Tln) activates integrins and links it to the actin cytoskeleton. Vertebrates contain two talin genes, tln1 and tln2. How Tln1 and Tln2...
12.
Zou W, Izawa T, Zhu T, Chappel J, Otero K, Monkley S, et al.
Mol Cell Biol
. 2012 Dec;
33(4):830-44.
PMID: 23230271
To determine talin1's role in osteoclasts, we mated TLN1(fl/fl) mice with those expressing cathepsin K-Cre (CtsK-TLN1) to delete the gene in mature osteoclasts or with lysozyme M-Cre (LysM-TLN1) mice to...
13.
Debrand E, Conti F, Bate N, Spence L, Mazzeo D, Pritchard C, et al.
Biochem Biophys Res Commun
. 2012 Aug;
426(2):190-5.
PMID: 22925892
Mice homozygous for several Tln2 gene targeted alleles are viable and fertile. Here we show that although the expression of talin2 protein is drastically reduced in muscle from these mice,...
14.
Bate N, Gingras A, Bachir A, Horwitz R, Ye F, Patel B, et al.
PLoS One
. 2012 Apr;
7(4):e34461.
PMID: 22496808
Talin is a large (∼2540 residues) dimeric adaptor protein that associates with the integrin family of cell adhesion molecules in cell-extracellular matrix junctions (focal adhesions; FAs), where it both activates...
15.
Lefort C, Rossaint J, Moser M, Petrich B, Zarbock A, Monkley S, et al.
Blood
. 2012 Mar;
119(18):4275-82.
PMID: 22431571
In inflammation, neutrophils and other leukocytes roll along the microvascular endothelium before arresting and transmigrating into inflamed tissues. Arrest requires conformational activation of the integrin lymphocyte function-associated antigen-1 (LFA-1). Mutations...
16.
Banno A, Goult B, Lee H, Bate N, Critchley D, Ginsberg M
J Biol Chem
. 2012 Feb;
287(17):13799-812.
PMID: 22351767
Talin, which is composed of head (THD) and rod domains, plays an important role in cell adhesion events in diverse species including most metazoans and Dictyostelium discoideum. Talin is abundant...
17.
Praekelt U, Kopp P, Rehm K, Linder S, Bate N, Patel B, et al.
Eur J Cell Biol
. 2012 Feb;
91(3):180-91.
PMID: 22306379
Talins are adaptor proteins that connect the integrin family of cell adhesion receptors to cytoskeletal actin. Vertebrates express two closely related talins encoded by separate genes, and while it is...
18.
Bouaouina M, Goult B, Huet-Calderwood C, Bate N, Brahme N, Barsukov I, et al.
J Biol Chem
. 2012 Jan;
287(10):6979-90.
PMID: 22235127
The activation of heterodimeric integrin adhesion receptors from low to high affinity states occurs in response to intracellular signals that act on the short cytoplasmic tails of integrin β subunits....
19.
Wernimont S, Wiemer A, Bennin D, Monkley S, Ludwig T, Critchley D, et al.
J Immunol
. 2011 Nov;
187(12):6256-67.
PMID: 22075696
T cell-APC contact initiates T cell activation and is maintained by the integrin LFA-1. Talin1, an LFA-1 regulator, localizes to the immune synapse (IS) with unknown roles in T cell...
20.
Truttmann M, Misselwitz B, Huser S, Hardt W, Critchley D, Dehio C
J Cell Sci
. 2011 Nov;
124(Pt 21):3591-602.
PMID: 22045736
The VirB/D4 type IV secretion system (T4SS) of the bacterial pathogen Bartonella henselae (Bhe) translocates seven effector proteins (BepA-BepG) into human cells that subvert host cellular functions. Two redundant pathways...