Gordon C K Roberts
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Explore the profile of Gordon C K Roberts including associated specialties, affiliations and a list of published articles.
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43
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1478
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Recent Articles
1.
Freeman S, Martel A, Devos J, Basran J, Raven E, Roberts G
J Biol Chem
. 2018 Feb;
293(14):5210-5219.
PMID: 29475945
Electron transfer in all living organisms critically relies on formation of complexes between the proteins involved. The function of these complexes requires specificity of the interaction to allow for selective...
2.
Freeman S, Martel A, Raven E, Roberts G
Sci Rep
. 2017 Aug;
7(1):9741.
PMID: 28852004
NADPH-cytochrome P450 reductase is a multi-domain redox enzyme which is a key component of the P450 mono-oxygenase drug-metabolizing system. We report studies of the conformational equilibrium of this enzyme using...
3.
Montagner C, Nigen M, Jacquin O, Willet N, Dumoulin M, Karsisiotis A, et al.
J Biol Chem
. 2016 May;
291(31):16124-37.
PMID: 27235401
Metallo-β-lactamases catalyze the hydrolysis of most β-lactam antibiotics and hence represent a major clinical concern. The development of inhibitors for these enzymes is complicated by the diversity and flexibility of...
4.
Karsisiotis A, Damblon C, Roberts G
Biochem J
. 2013 Sep;
456(3):397-407.
PMID: 24059435
Metallo-β-lactamases, enzymes which inactivate β-lactam antibiotics, are of increasing biological and clinical significance as a source of antibiotic resistance in pathogenic bacteria. In the present study we describe the high-resolution...
5.
Huang W, Ellis J, Moody P, Raven E, Roberts G
Structure
. 2013 Aug;
21(9):1581-9.
PMID: 23911089
NADPH-cytochrome P450 reductase is a key component of the P450 mono-oxygenase drug-metabolizing system. There is evidence for a conformational equilibrium involving large-scale domain motions in this enzyme. We now show,...
6.
Karsisiotis A, Damblon C, Roberts G
Biomol NMR Assign
. 2013 Jul;
8(2):313-8.
PMID: 23838816
β-Lactamases inactivate β-lactam antibiotics by hydrolysis of their endocyclic β-lactam bond and are a major cause of antibiotic resistance in pathogenic bacteria. The zinc dependent metallo-β-lactamase enzymes are of particular...
7.
Goult B, Zacharchenko T, Bate N, Tsang R, Hey F, Gingras A, et al.
J Biol Chem
. 2013 Feb;
288(12):8238-8249.
PMID: 23389036
Talin activates integrins, couples them to F-actin, and recruits vinculin to focal adhesions (FAs). Here, we report the structural characterization of the talin rod: 13 helical bundles (R1-R13) organized into...
8.
Jenner M, Ellis J, Huang W, Raven E, Roberts G, Oldham N
Angew Chem Int Ed Engl
. 2011 Jun;
50(36):8291-4.
PMID: 21688358
No abstract available.
9.
Huang W, Cullis P, Raven E, Roberts G
Metallomics
. 2011 Jan;
3(4):410-6.
PMID: 21240430
The potential of flavocytochrome P450 BM3 (CYP102A1) from Bacillus megaterium for biocatalysis and biotechnological application is widely acknowledged. The catalytic and structural analysis of the Ala82Phe mutant of P450 BM3...
10.
Elliott P, Goult B, Kopp P, Bate N, Grossmann J, Roberts G, et al.
Structure
. 2010 Oct;
18(10):1289-99.
PMID: 20947018
FERM domains are found in a diverse superfamily of signaling and adaptor proteins at membrane interfaces. They typically consist of three separately folded domains (F1, F2, F3) in a compact...