David M Tarlinton
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Explore the profile of David M Tarlinton including associated specialties, affiliations and a list of published articles.
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115
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6514
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Recent Articles
11.
Di Pietro A, Polmear J, Cooper L, Damelang T, Hussain T, Hailes L, et al.
Nat Immunol
. 2021 Nov;
23(1):86-98.
PMID: 34845392
Ineffective antibody-mediated responses are a key characteristic of chronic viral infection. However, our understanding of the intrinsic mechanisms that drive this dysregulation are unclear. Here, we identify that targeting the...
12.
Kato Y, Steiner T, Park H, Hitchcock R, Zaid A, Hor J, et al.
J Immunol
. 2020 Aug;
205(7):1842-1856.
PMID: 32839238
Follicular dendritic cells and macrophages have been strongly implicated in presentation of native Ag to B cells. This property has also occasionally been attributed to conventional dendritic cells (cDC) but...
13.
Robinson M, Webster R, Tarlinton D
Immunol Rev
. 2020 Jun;
296(1):87-103.
PMID: 32592168
Plasma cells (PC) are key to protective immunity because they secrete antibodies. Surviving for periods ranging from days to decades in mammals, PC possess varying survival times that cannot be...
14.
Ng A, Coughlan H, Hediyeh-Zadeh S, Behrens K, Johanson T, Low M, et al.
Nat Commun
. 2020 Jun;
11(1):3013.
PMID: 32541654
B lymphoid development is initiated by the differentiation of hematopoietic stem cells into lineage committed progenitors, ultimately generating mature B cells. This highly regulated process generates clonal immunological diversity via...
15.
Jackson J, ODonnell K, Light A, Goh W, Huntington N, Tarlinton D, et al.
Eur J Immunol
. 2020 Feb;
50(7):959-971.
PMID: 32090320
The transcription factor Hhex (hematopoietically expressed homeobox gene) is critical for development of multiple lymphoid lineages beyond the common lymphoid progenitor. In addition, Hhex regulates hematopoietic stem cell (HSC) self-renewal,...
16.
Sakakibara S, Yasui T, Jinzai H, ODonnell K, Tsai C, Minamitani T, et al.
Int Immunol
. 2019 Sep;
32(1):27-38.
PMID: 31504561
Immune responses against certain viruses are accompanied by auto-antibody production although the origin of these infection-associated auto-antibodies is unclear. Here, we report that murine γ-herpesvirus 68 (MHV68)-induced auto-antibodies are derived...
17.
Robinson M, Pitt C, Brodie E, Valk A, ODonnell K, Nitschke L, et al.
Immunol Cell Biol
. 2019 Jul;
97(9):826-839.
PMID: 31276232
A B cell culture system using BAFF, IL-4 and IL-21 was recently developed that generates B cells with phenotypic and functional characteristics of in vivo-generated germinal center (GC) B cells....
18.
Liu R, King A, Bouillet P, Tarlinton D, Strasser A, Heierhorst J
Front Immunol
. 2018 Apr;
9:592.
PMID: 29623080
The proapoptotic BH3-only protein BIM () plays key roles in the maintenance of multiple hematopoietic cell types. In mice, germline knockout or conditional pan-hematopoietic deletion of results in marked splenomegaly...
19.
Zhang Y, Tech L, George L, Acs A, Durrett R, Hess H, et al.
J Exp Med
. 2018 Mar;
215(4):1227-1243.
PMID: 29549115
Germinal centers (GCs) are the sites where B cells undergo affinity maturation. The regulation of cellular output from the GC is not well understood. Here, we show that from the...
20.
Brodie E, Infantino S, Low M, Tarlinton D
Front Immunol
. 2018 Mar;
9:401.
PMID: 29545808
Systemic lupus erythematosus (SLE) is a progressive autoimmune disease characterized by increased sensitivity to self-antigens, auto-antibody production, and systemic inflammation. B cells have been implicated in disease progression and as...