Amanda Light
Overview
Explore the profile of Amanda Light including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
27
Citations
1506
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0
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Recent Articles
1.
Atkin-Smith G, Santavanond J, Light A, Rimes J, Samson A, Er J, et al.
Nat Commun
. 2024 Oct;
15(1):8802.
PMID: 39438460
Endothelial cells are integral components of all vasculature within complex organisms. As they line the blood vessel wall, endothelial cells are constantly exposed to a variety of molecular factors and...
2.
Smirnova N, Cross S, Light A, Kavalieratos D
Respir Med
. 2024 Jun;
231:107719.
PMID: 38908412
No abstract available.
3.
Chiou S, Al-Ani A, Pan Y, Patel K, Kong I, Whitehead L, et al.
EMBO Mol Med
. 2024 May;
16(7):1717-1749.
PMID: 38750308
Necroptosis is a lytic form of regulated cell death reported to contribute to inflammatory diseases of the gut, skin and lung, as well as ischemic-reperfusion injuries of the kidney, heart...
4.
Kong I, Trezise S, Light A, Todorovski I, Arnau G, Gadipally S, et al.
Cell Death Differ
. 2022 Jul;
29(12):2519-2530.
PMID: 35831623
High-throughput methodologies are the cornerstone of screening approaches to identify novel compounds that regulate immune cell function. To identify novel targeted therapeutics to treat immune disorders and haematological malignancies, there...
5.
Kong I, Rimes J, Light A, Todorovski I, Jones S, Morand E, et al.
Cell Rep
. 2020 Oct;
33(3):108290.
PMID: 33086063
JQ1 is a BET-bromodomain inhibitor that has immunomodulatory effects. However, the precise molecular mechanism that JQ1 targets to elicit changes in antibody production is not understood. Our results show that...
6.
Jackson J, ODonnell K, Light A, Goh W, Huntington N, Tarlinton D, et al.
Eur J Immunol
. 2020 Feb;
50(7):959-971.
PMID: 32090320
The transcription factor Hhex (hematopoietically expressed homeobox gene) is critical for development of multiple lymphoid lineages beyond the common lymphoid progenitor. In addition, Hhex regulates hematopoietic stem cell (HSC) self-renewal,...
7.
Lalaoui N, Boyden S, Oda H, Wood G, Stone D, Chau D, et al.
Nature
. 2019 Dec;
577(7788):103-108.
PMID: 31827281
RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is regulated post-translationally by well-characterized ubiquitylation and phosphorylation events, as well as by...
8.
Willis S, Tellier J, Liao Y, Trezise S, Light A, ODonnell K, et al.
Nat Commun
. 2017 Nov;
8(1):1426.
PMID: 29127283
Humoral immunity requires B cells to respond to multiple stimuli, including antigen, membrane and soluble ligands, and microbial products. Ets family transcription factors regulate many aspects of haematopoiesis, although their...
9.
Infantino S, Light A, ODonnell K, Bryant V, Avery D, Elliott M, et al.
Nat Commun
. 2017 Oct;
8(1):891.
PMID: 29026071
Arginine methylation catalyzed by protein arginine methyltransferases (PRMT) is a common post-translational modification in mammalian cells, regulating many important functions including cell signalling, proliferation and differentiation. Here we show the...
10.
Jones S, Toh A, Odobasic D, Oudin M, Cheng Q, Lee J, et al.
Ann Rheum Dis
. 2015 Nov;
75(4):739-47.
PMID: 26612340
Objectives: Systemic lupus erythematosus (SLE) is a serious multisystem autoimmune disease, mediated by disrupted B cell quiescence and typically treated with glucocorticoids. We studied whether B cells in SLE are...