Plasma Cell Output from Germinal Centers is Regulated by Signals from Tfh and Stromal Cells

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2018 Mar 18

PMID 29549115

Citations 66

Authors

Yang Zhang

Laura Tech

Laura A George

Andreas Acs

Russell E Durrett

Henry Hess

Lucy S K Walker

David M Tarlinton

Anne L Fletcher

Anja Erika Hauser

Kai-Michael Toellner

Affiliations

Soon will be listed here.

Abstract

Germinal centers (GCs) are the sites where B cells undergo affinity maturation. The regulation of cellular output from the GC is not well understood. Here, we show that from the earliest stages of the GC response, plasmablasts emerge at the GC-T zone interface (GTI). We define two main factors that regulate this process: Tfh-derived IL-21, which supports production of plasmablasts from the GC, and TNFSF13 (APRIL), which is produced by a population of podoplanin CD157 fibroblastic reticular cells located in the GTI that are also rich in message for IL-6 and chemokines CXCL12, CCL19, and CCL21. Plasmablasts in the GTI express the APRIL receptor TNFRSF13B (TACI), and blocking TACI interactions specifically reduces the numbers of plasmablasts appearing in the GTI. Plasma cells generated in the GTI may provide an early source of affinity-matured antibodies that may neutralize pathogens or provide feedback regulating GC B cell selection.

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