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David M Selva

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Articles 38
Citations 867
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Recent Articles
1.
Goedecke J, Kufe C, Masemola M, Lichaba M, Seipone I, Mendham A, et al.
medRxiv . 2025 Jan; PMID: 39763542
Objectives: Sex hormone-binding globulin (SHBG) and testosterone are differentially associated with type 2 diabetes (T2D) risk. We investigated whether these associations differ by HIV and menopausal status in Black South...
2.
Brianso-Llort L, Saez-Lopez C, Alvarez-Guaita A, Ramos-Perez L, Hernandez C, Simo R, et al.
Mol Nutr Food Res . 2024 Jun; 68(14):e2400020. PMID: 38934352
Sex hormone-binding globulin (SHBG) is a homodimeric glycoprotein produced by the human liver and secreted into the systemic circulation where it binds with high affinity sex steroids regulating their availability...
3.
Brianso-Llort L, Fuertes-Rioja L, Ramos-Perez L, Salcedo-Allende M, Hernandez C, Simo R, et al.
J Cell Physiol . 2022 Jun; 237(9):3598-3613. PMID: 35762039
Low plasma sex hormone-binding globulin (SHBG) levels are present in fatty liver disease, which represents a spectrum of diseases ranging from hepatocellular steatosis through steatohepatitis to fibrosis and irreversible cirrhosis....
4.
Brianso-Llort L, Simo-Servat O, Ramos-Perez L, Torres-Torronteras J, Hernandez C, Simo R, et al.
Mol Nutr Food Res . 2022 Jun; 66(16):e2200125. PMID: 35751841
Scope: Low sex hormone-binding globulin (SHBG) levels are associated with higher risk of developing cardiovascular disease. Epidemiological studies have shown that red wine has beneficial effects on cardiovascular disease. In...
5.
Ramon-Krauel M, Leal-Witt M, Osorio-Conles O, Amat-Bou M, Lerin C, Selva D
Mol Cell Pediatr . 2021 Mar; 8(1):3. PMID: 33689083
Background: Sex hormone-binding globulin (SHBG) levels are low in adult subjects with obesity when compared to normal-weight individuals. Obesity is associated with higher tumor necrosis factor alpha (TNFα) plasma levels...
6.
Saez-Lopez C, Villena J, Simo R, Selva D
J Nutr Biochem . 2020 Aug; 85:108480. PMID: 32795655
Obese subjects of all ages and sex have reduced plasma SHBG levels. Whether these low plasma SHBG levels play a role in obesity development is unknown. In the present work...
7.
Brianso-Llort L, Fuertes-Rioja L, Ramos-Perez L, Hernandez C, Simo R, Selva D
Mol Nutr Food Res . 2020 Jul; 64(17):e1901253. PMID: 32652892
Scope: Epidemiological studies have shown that caffeine increases serum sex hormone-binding globulin (SHBG) levels. The relationship between caffeine and SHBG production has never been studied before at molecular level. The...
8.
Saez-Lopez C, Salcedo-Allende M, Hernandez C, Simo-Servat O, Simo R, Selva D
J Clin Endocrinol Metab . 2018 Nov; 104(5):1500-1507. PMID: 30496542
Context: There is emerging evidence that SHBG is substantially reduced in chronic metabolic diseases, including obesity and nonalcoholic fatty liver disease (NAFLD). We have recently reported, through use of in...
9.
Saez-Lopez C, Brianso-Llort L, Torres-Torronteras J, Simo R, Hammond G, Selva D
Sci Rep . 2018 Mar; 8(1):5046. PMID: 29555933
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
10.
Saez-Lopez C, Brianso-Llort L, Torres-Torronteras J, Simo R, Hammond G, Selva D
Sci Rep . 2017 Sep; 7(1):12284. PMID: 28947831
Sex hormone-binding globulin (SHBG) carries sex steroids in blood regulating their bioavailability. Red wine consumption increases plasma SHBG levels, and we have discovered that resveratrol, a polyphenol enriched in red...