Geoffrey L Hammond
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Explore the profile of Geoffrey L Hammond including associated specialties, affiliations and a list of published articles.
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93
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1551
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Recent Articles
1.
Boyle L, Miguelez-Crespo A, Paul M, Villalobos E, Toews J, Ivatt L, et al.
Nat Commun
. 2025 Jan;
16(1):545.
PMID: 39788946
Corticosteroid binding globulin (CBG; SERPINA6) binds >85% of circulating glucocorticoids but its influence on their metabolic actions is unproven. Targeted proteolytic cleavage of CBG by neutrophil elastase (NE; ELANE) significantly...
2.
Toews J, Philippe T, Dordevic M, Hill L, Hammond G, Viau V
Endocrinology
. 2023 Nov;
165(1).
PMID: 38015819
Produced by the liver, corticosteroid-binding globulin (CBG) regulates the plasma distribution and actions of glucocorticoids. A sex difference in pituitary growth hormone secretion patterns established during puberty in rats results...
3.
Toews J, Philippe T, Hill L, Dordevic M, Miguelez-Crespo A, Homer N, et al.
Endocrinology
. 2022 Sep;
163(11).
PMID: 36112420
Encoded by SerpinA6, plasma corticosteroid-binding globulin (CBG) transports glucocorticoids and regulates their access to cells. We determined how CBG influences plasma corticosterone and adrenal development in rats during the pubertal...
4.
Frobert A, Toews J, Nielsen C, Brohus M, Kindberg J, Jessen N, et al.
Physiol Biochem Zool
. 2022 Jul;
95(5):365-378.
PMID: 35839518
Brown bears are obese when they enter the den, and after 6 mo of hibernation and physical inactivity, bears show none of the adverse consequences of a sedentary lifestyle in...
5.
Frobert A, Brohus M, Toews J, Round P, Frobert O, Hammond G, et al.
FEBS Open Bio
. 2021 Dec;
12(2):362-378.
PMID: 34855305
Sex hormone-binding globulin (SHBG) regulates the bioavailability of sex steroid hormones in the blood. Levels of SHBG increase markedly in brown bears (Ursus arctos) during hibernation, suggesting that a key...
6.
Andriessen V, Lightbourne M, Flippo C, Faucz F, Delaney A, Hannah-Shmouni F, et al.
J Endocr Soc
. 2021 Aug;
5(10):bvab125.
PMID: 34405127
Sex hormone-binding globulin (SHBG) in the blood is a major determinant of bioactivity for key sex steroids such as testosterone and estradiol. Low serum levels of SHBG have been associated...
7.
Kumaran K, Krishnaveni G, Suryanarayana K, Prasad M, Belavendra A, Atkinson S, et al.
BMJ Open
. 2021 Feb;
11(2):e045862.
PMID: 33593789
Introduction: The Healthy Life Trajectories Initiative is an international consortium comprising four harmonised but independently powered trials to evaluate whether an integrated intervention starting preconceptionally will reduce non-communicable disease risk...
8.
Toews J, Hammond G, Viau V
J Endocrinol
. 2020 Oct;
248(1):R1-R17.
PMID: 33112814
Normal function of the hypothalamic-pituitary-adrenal (HPA) axis is critical for survival, and its development is choreographed for age-, sex- and context-specific actions. The liver influences HPA ontogeny, integrating diverse endocrine...
9.
Round P, Das S, Wu T, Wahala K, Van Petegem F, Hammond G
J Biol Chem
. 2019 Dec;
295(5):1202-1211.
PMID: 31852737
Sex hormone-binding globulin (SHBG) determines the equilibrium between free and protein-bound androgens and estrogens in the blood and regulates their access to target tissues. Using crystallographic approaches and radiolabeled competitive...
10.
Hill L, Sumer-Bayraktar Z, Lewis J, Morava E, Thaysen-Andersen M, Hammond G
Endocr Connect
. 2019 Jul;
8(8):1136-1148.
PMID: 31307013
Objective: Discrepancies in ELISA measurements of human corticosteroid-binding globulin (CBG) using detection monoclonal antibodies that recognize an epitope (9G12) within its reactive center loop (RCL), versus an epitope (12G2) in...