David J Tremethick
Overview
Explore the profile of David J Tremethick including associated specialties, affiliations and a list of published articles.
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41
Citations
2067
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Recent Articles
1.
Wong L, Tremethick D
Nat Rev Genet
. 2024 Aug;
26(2):82-104.
PMID: 39138293
Histones are integral components of eukaryotic chromatin that have a pivotal role in the organization and function of the genome. The dynamic regulation of chromatin involves the incorporation of histone...
2.
Dijkwel Y, Hart-Smith G, Kurscheid S, Tremethick D
Mol Cell Biol
. 2024 Mar;
44(2):72-85.
PMID: 38482865
ANP32e, a chaperone of H2A.Z, is receiving increasing attention because of its association with cancer growth and progression. An unanswered question is whether ANP32e regulates H2A.Z dynamics during the cell...
3.
Dijkwel Y, Tremethick D
J Dev Biol
. 2022 Jul;
10(3).
PMID: 35893123
During the emergence and radiation of complex multicellular eukaryotes from unicellular ancestors, transcriptional systems evolved by becoming more complex to provide the basis for this morphological diversity. The way eukaryotic...
4.
Niederacher G, Urwin D, Dijkwel Y, Tremethick D, Rosengren K, Becker C, et al.
RSC Chem Biol
. 2021 Aug;
2(2):537-550.
PMID: 34458797
Interactions between histones, which package DNA in eukaryotes, and nuclear proteins such as the high mobility group nucleosome-binding protein HMGN1 are important for regulating access to DNA. HMGN1 is a...
5.
Nekrasov M, Tremethick D
Methods Mol Biol
. 2021 Aug;
2351:147-161.
PMID: 34382188
Sequential ChIP (ChIP-reChIP) enables the characterization of the same nucleosome for two different types of modifications or histone subtypes. Here, we describe a ChIP-reChIP protocol to identify a heterotypic (asymmetric)...
6.
Jiang X, Wen J, Paver E, Wu Y, Sun G, Bullman A, et al.
EMBO Rep
. 2021 Aug;
22(8):e52462.
PMID: 34350706
Testis-specific regulators of chromatin function are commonly ectopically expressed in human cancers, but their roles are poorly understood. Examination of 81 primary Hodgkin lymphoma (HL) samples showed that the ectopic...
7.
Cole L, Kurscheid S, Nekrasov M, Domaschenz R, Vera D, Dennis J, et al.
Nat Commun
. 2021 May;
12(1):2524.
PMID: 33953180
Chromatin accessibility of a promoter is fundamental in regulating transcriptional activity. The histone variant H2A.Z has been shown to contribute to this regulation, but its role has remained poorly understood....
8.
Jiang X, Soboleva T, Tremethick D
Cells
. 2020 Apr;
9(4).
PMID: 32252453
The dynamic packaging of DNA into chromatin regulates all aspects of genome function by altering the accessibility of DNA and by providing docking pads to proteins that copy, repair and...
9.
Anuar N, Kurscheid S, Field M, Zhang L, Rebar E, Gregory P, et al.
Genome Biol
. 2019 Feb;
20(1):23.
PMID: 30704500
Background: Altering the biochemical makeup of chromatin by the incorporation of histone variants during development represents a key mechanism in regulating gene expression. The histone variant H2A.B, H2A.B.3 in mice,...
10.
Soboleva T, Tremethick D
Methods Mol Biol
. 2018 Aug;
1832:169-184.
PMID: 30073527
Chromatin is a dynamic macromolecular structure comprised of histones and a wealth of non-histone proteins. Recently, it has become clear that RNA is also an integral component of chromatin playing...