Richard K Grencis
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Explore the profile of Richard K Grencis including associated specialties, affiliations and a list of published articles.
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93
Citations
3343
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Recent Articles
1.
Layton E, Goldsworthy S, Yang E, Ong W, Sutherland T, Bancroft A, et al.
Nat Commun
. 2025 Feb;
16(1):1589.
PMID: 39939598
The intestine is a site of diverse functions including digestion, nutrient absorption, immune surveillance, and microbial symbiosis. Intestinal microRNAs (miRNAs) are detectable in faeces and regulate barrier integrity, host-microbe interactions...
2.
Goulding D, Tolley C, Mkandawire T, Doyle S, Hart E, Airs P, et al.
PLoS Pathog
. 2025 Jan;
21(1):e1012502.
PMID: 39869639
Whipworms (Trichuris spp) are ubiquitous parasites of humans and domestic and wild mammals that cause chronic disease, considerably impacting human and animal health. Egg hatching is a critical phase in...
3.
Dubaissi E, Hilton E, Lilley S, Collins R, Holt C, March P, et al.
Sci Rep
. 2024 Oct;
14(1):25555.
PMID: 39461969
The TMEM16A chloride channel is proposed as a therapeutic target in cystic fibrosis, where activation of this ion channel might restore airway surface hydration and mitigate respiratory symptoms. While TMEM16A...
4.
Bay O, Hayes K, Schwartz J, Grencis R, Roberts I
Nat Commun
. 2023 Nov;
14(1):6937.
PMID: 37907472
Genome-scale metabolic models are widely used to enhance our understanding of metabolic features of organisms, host-pathogen interactions and to identify therapeutics for diseases. Here we present iTMU798, the genome-scale metabolic...
5.
Funjika E, Colombo S, Hayes K, Tozer M, Tyrrell K, Cai S, et al.
Mucosal Immunol
. 2023 Jan;
16(1):27-38.
PMID: 36690078
Gastrointestinal nematode infections cause morbidity and socioeconomic loss in the most deprived communities. The shift in the context of obesity has led to spatial overlap with endemic gastrointestinal nematode regions...
6.
Hodge S, Krauss M, Kaymak I, King J, Howden A, Panic G, et al.
J Exp Med
. 2022 Dec;
220(3).
PMID: 36571761
Group 2 innate lymphoid cells (ILC2) are functionally poised, tissue-resident lymphocytes that respond rapidly to damage and infection at mucosal barrier sites. ILC2 reside within complex microenvironments where they are...
7.
Shears R, Grencis R
Parasit Vectors
. 2022 Sep;
15(1):348.
PMID: 36175934
Whipworm (Trichuris) is a genus of roundworms that causes gastrointestinal infections in humans and animals. Of particular interest are T. trichiura, the causative agent of human trichuriasis, a neglected tropical...
8.
Penny H, Domingues R, Krauss M, Melo-Gonzalez F, Lawson M, Dickson S, et al.
Sci Immunol
. 2022 Sep;
7(75):eabk2541.
PMID: 36054336
Interactions between the mammalian host and commensal microbiota are enforced through a range of immune responses that confer metabolic benefits and promote tissue health and homeostasis. Immunoglobulin A (IgA) responses...
9.
Colombo S, Thompson S, Bancroft A, Grencis R
Parasite Immunol
. 2022 May;
44(8):e12936.
PMID: 35586956
In endemic regions concurrent infection with multiple gastrointestinal (GI) helminth species is more common than single species infection. However, the majority of model helminth infections focus on single species infections...
10.
Duque-Correa M, Goulding D, Rodgers F, Gillis J, Cormie C, Rawlinson K, et al.
Nat Commun
. 2022 Apr;
13(1):1725.
PMID: 35365634
Whipworms are large metazoan parasites that inhabit multi-intracellular epithelial tunnels in the large intestine of their hosts, causing chronic disease in humans and other mammals. How first-stage larvae invade host...