Michael A McGuckin
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Explore the profile of Michael A McGuckin including associated specialties, affiliations and a list of published articles.
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93
Citations
5751
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Recent Articles
1.
Sajiir H, Ramm G, Macdonald G, McGuckin M, Prins J, Hasnain S
Trends Mol Med
. 2024 Nov;
PMID: 39578121
Primarily perceived as an anti-inflammatory and antimicrobial mediator in mucosa and skin, interleukin-22 (IL-22) has emerged as a pivotal metabolic regulator. Central to IL-22 signaling is its receptor, IL-22RA1. Through...
2.
Sajiir H, Wong K, Muller A, Keshvari S, Burr L, Aiello E, et al.
Nat Commun
. 2024 May;
15(1):4527.
PMID: 38811550
The IL-22RA1 receptor is highly expressed in the pancreas, and exogenous IL-22 has been shown to reduce endoplasmic reticulum and oxidative stress in human pancreatic islets and promote secretion of...
3.
Sajiir H, Keshvari S, Wong K, Borg D, Steyn F, Fercher C, et al.
Nat Commun
. 2024 May;
15(1):4528.
PMID: 38811532
Metabolic dysfunction-associated steatohepatitis (MASH) is the most prevalent cause of liver disease worldwide, with a single approved therapeutic. Previous research has shown that interleukin-22 (IL-22) can suppress β-cell stress, reduce...
4.
Moniruzzaman M, Rahman M, Wang R, Wong K, Chen A, Mueller A, et al.
J Exp Med
. 2023 Sep;
220(11).
PMID: 37695525
Major histocompatibility complex (MHC) II is dynamically expressed on mucosal epithelial cells and is induced in response to inflammation and parasitic infections, upon exposure to microbiota, and is increased in...
5.
McGuckin M, Davies J, Felgner P, Wong K, Giri R, He Y, et al.
Cell Mol Gastroenterol Hepatol
. 2023 Sep;
16(6):985-1009.
PMID: 37660948
Background & Aims: MUC13 cell surface mucin is highly expressed on the mucosal surface throughout the intestine, yet its role against bacterial infection is unknown. We investigated how MUC13 impacts...
6.
Sheng Y, Davies J, Wang R, Wong K, Giri R, Yang Y, et al.
Cell Mol Gastroenterol Hepatol
. 2022 Jul;
14(4):789-811.
PMID: 35809803
Background & Aims: MUC1 is abnormally expressed in colorectal cancer, including colitis-associated colorectal cancer (CAC), but its role in tumorigenesis is unclear. This study investigated MUC1's effects in murine models...
7.
Giri R, Hoedt E, Khushi S, Salim A, Bergot A, Schreiber V, et al.
Cell Rep
. 2022 Apr;
39(2):110646.
PMID: 35417687
Emerging evidence suggests that microbiome-host crosstalk regulates intestinal immune activity and predisposition to inflammatory bowel disease (IBD). NF-κB is a master regulator of immune function and a validated target for...
8.
Wang R, Moniruzzaman M, Wong K, Wiid P, Harding A, Giri R, et al.
Gut Microbes
. 2021 Mar;
13(1):1-18.
PMID: 33645438
Intestinal epithelial cell endoplasmic reticulum (ER) stress has been implicated in intestinal inflammation. It remains unclear whether ER stress is an initiator of or a response to inflammation. mice, carrying...
9.
Sheng Y, Ng G, Summers K, Every A, Price G, Hasnain S, et al.
Front Cell Infect Microbiol
. 2020 Aug;
10:343.
PMID: 32793510
The cell surface mucin MUC1 is an important host factor limiting ) pathogenesis in both humans and mice by providing a protective barrier and modulating mucosal epithelial and leukocyte responses....
10.
Sheng Y, Giri R, Davies J, Schreiber V, Alabbas S, Movva R, et al.
Cell Mol Gastroenterol Hepatol
. 2020 Jun;
11(1):33-53.
PMID: 32497793
Background & Aims: Chronic bowel inflammation increases the risk of colon cancer; colitis-associated cancer (CAC). Thiopurine treatments are associated with a reduction in dysplasia and CAC in inflammatory bowel disease...