David J Orlicky
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Explore the profile of David J Orlicky including associated specialties, affiliations and a list of published articles.
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181
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3512
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Recent Articles
1.
Escobedo H, Zawadzki N, Till J, Vazquez-Torres A, Wang G, Simberg D, et al.
Nanomedicine
. 2025 Mar;
65:102812.
PMID: 40024488
Among hospital-acquired infections, Pseudomonas aeruginosa-associated urinary tract infections (UTIs) are mainly caused by indwelling urethral catheters (catheter-associated UTIs or CAUTIs) and are difficult to treat, resulting in high rates of...
2.
Kremer K, Khammash H, Miranda A, Rutt L, Twardy S, Anton P, et al.
Front Immunol
. 2025 Feb;
15:1497788.
PMID: 39896805
As a metabolic center, the liver prevents inappropriate immune responses to abundant dietary antigens within the liver that could result in liver injury. This self-preservation mechanism can however decrease the...
3.
Grayck M, Smith B, Sosa A, Golden E, McCarthy W, Solar M, et al.
Am J Respir Cell Mol Biol
. 2025 Jan;
PMID: 39836061
Whether early life acetaminophen (APAP) exposures injure the developing lung is controversial. We sought to correlate murine pulmonary developmental expression profiles of to susceptibility to APAP exposure. P14 C57BL/6 mice...
4.
Rutt L, Orlicky D, McCullough R
Cell Biol Toxicol
. 2024 Dec;
41(1):5.
PMID: 39707064
Toxicant exposure can lead to acute liver injury, characterized by hepatic reprogramming and wound healing. Hepatic stellate cells (HSC) play a key role in liver regeneration during wound healing by...
5.
Shearn C, Anderson A, Devereaux M, Koch S, Larsen L, Spencer L, et al.
Hepatol Commun
. 2024 Nov;
8(12).
PMID: 39585296
Background: Intestinal inflammation is a common factor in ~70% of patients diagnosed with primary sclerosing cholangitis. The TNF∆ARE+/- mouse overexpresses TNFα and spontaneously develops ileitis after weaning. The aim of...
6.
Walrath T, Najarro K, Giesy L, Khair S, Orlicky D, McMahan R, et al.
FASEB J
. 2024 Sep;
38(18):e70065.
PMID: 39305117
One in six people are projected to be 65 years or older by 2050. As the population ages, better treatments for injuries that disproportionately impact the aged population will be...
7.
Wang Y, Charkoftaki G, Orlicky D, Davidson E, Aalizadeh R, Sun N, et al.
Arch Toxicol
. 2024 Aug;
98(10):3241-3257.
PMID: 39192018
1,4-Dioxane (DX), an emerging water contaminant, is classified as a Group 2B liver carcinogen based on animal studies. Understanding of the mechanisms of action of DX liver carcinogenicity is important...
8.
Burtis A, DeNicola D, Ferguson M, Santos R, Pinilla C, Kriss M, et al.
Hepatology
. 2024 Jul;
81(2):591-608.
PMID: 39047085
Background And Aims: Chronic liver disease due to metabolic dysfunction-associated steatohepatitis (MASH) is a rapidly increasing global epidemic. MASH progression is a consequence of the complex interplay between inflammatory insults...
9.
Andres-Hernando A, Orlicky D, Kuwabara M, Fini M, Tolan D, Johnson R, et al.
Commun Biol
. 2024 Jul;
7(1):849.
PMID: 38992061
Hereditary fructose intolerance (HFI) is a painful and potentially lethal genetic disease caused by a mutation in aldolase B resulting in accumulation of fructose-1-phosphate (F1P). No cure exists for HFI...
10.
Maclean K, Jiang H, Neill P, Chanin R, Hurt K, Orlicky D, et al.
FASEB J
. 2024 Jul;
38(13):e23795.
PMID: 38984928
Cystathionine beta-synthase-deficient homocystinuria (HCU) is a life-threatening disorder of sulfur metabolism. HCU can be treated by using betaine to lower tissue and plasma levels of homocysteine (Hcy). Here, we show...