Dennis R Petersen
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Explore the profile of Dennis R Petersen including associated specialties, affiliations and a list of published articles.
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77
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2775
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Recent Articles
1.
Shearn C, Anderson A, Devereux M, Orlicky D, Michel C, Petersen D, et al.
PLoS One
. 2022 Nov;
17(11):e0276879.
PMID: 36378690
Inflammatory cholestatic liver diseases, including Primary Sclerosing Cholangitis (PSC), are characterized by periportal inflammation with progression to cirrhosis. The objective of this study was to examine interactions between oxidative stress...
2.
Shearn C, Fennimore B, Orlicky D, Gao Y, Saba L, Battista K, et al.
Free Radic Biol Med
. 2019 Aug;
143:101-114.
PMID: 31377417
Cholangiopathies such as primary sclerosing cholangitis (PSC) are chronic liver diseases characterized by increased cholestasis, biliary inflammation and oxidative stress. The objective of this study was to elucidate the impact...
3.
Petersen D, Orlicky D, Roede J, Shearn C
Exp Mol Pathol
. 2018 Jun;
105(1):32-36.
PMID: 29852184
Objective: Primary Sclerosing Cholangitis (PSC) is a severe cholestatic liver disease characterized by progressive peri-biliary tract inflammation, elevated oxidative stress and hepatocellular injury. A hallmark of PSC patients is the...
4.
Petersen D, Saba L, Sayin V, Papagiannakopoulos T, Schmidt E, Merrill G, et al.
PLoS One
. 2018 May;
13(5):e0198139.
PMID: 29799837
Objective: In the liver, a contributing factor in the pathogenesis of non-alcoholic fatty liver disease (NASH) is oxidative stress, which leads to the accumulation of highly reactive electrophilic α/β unsaturated...
5.
Shearn C, Pulliam C, Pedersen K, Meredith K, Mercer K, Saba L, et al.
Alcohol Clin Exp Res
. 2018 May;
42(7):1192-1205.
PMID: 29708596
Background: Glutathione S-transferase A4-4 (GSTA4) is a key enzyme for removal of toxic lipid peroxidation products such as 4-hydroxynonenal (4-HNE). In this study, we examined the potential role of GSTA4...
6.
Kharbanda K, Ronis M, Shearn C, Petersen D, Zakhari S, Warner D, et al.
Biomolecules
. 2018 Mar;
8(2).
PMID: 29587455
The symposium, "Role of Nutrition in Alcoholic Liver Disease", was held at the European Society for Biomedical Research on Alcoholism Congress on 9 October 2017 in Crete, Greece. The goal...
7.
Shearn C, Orlicky D, Petersen D
Exp Mol Pathol
. 2017 Nov;
104(1):1-8.
PMID: 29180269
Objective: Primary Sclerosing Cholangitis (PSC) is a chronic cholestatic liver disease that is characterized by severe peri-biliary tract inflammation and fibrosis, elevated oxidative stress and hepatocellular injury. A hallmark of...
8.
Maclean K, Jiang H, Aivazidis S, Kim E, Shearn C, Harris P, et al.
FASEB J
. 2017 Nov;
32(3):1265-1280.
PMID: 29101223
Cystathionine β-synthase-deficient homocystinuria (HCU) is a poorly understood, life-threatening inborn error of sulfur metabolism. Analysis of hepatic glutathione (GSH) metabolism in a mouse model of HCU demonstrated significant depletion of...
9.
Shearn C, Saba L, Roede J, Orlicky D, Shearn A, Petersen D
Free Radic Biol Med
. 2017 Oct;
113:280-290.
PMID: 28988798
Objective: In the liver, a contributing factor in the pathogenesis of non-alcoholic fatty liver disease is oxidative stress leading to the accumulation of highly reactive electrophilic α/β unsaturated aldehydes. The...
10.
Osna N, Carter W, Ganesan M, Kirpich I, McClain C, Petersen D, et al.
World J Gastroenterol
. 2016 Jul;
22(27):6192-200.
PMID: 27468209
It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby...