David J H F Knapp
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Explore the profile of David J H F Knapp including associated specialties, affiliations and a list of published articles.
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52
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1805
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Recent Articles
1.
Hunt J, du Rand A, Verdon D, Clemance L, Loef E, Malhi C, et al.
Mol Ther Nucleic Acids
. 2025 Mar;
36(1):102472.
PMID: 40027886
Gene editing facilitated by homology-directed repair (HDR) holds great potential for treating monogenetic disorders such as recessive dystrophic epidermolysis bullosa (RDEB). However, low efficiency and variability between loci must be...
2.
Michaels Y, Major M, Bonham-Carter B, Zhang J, Heydari T, Edgar J, et al.
Cell Syst
. 2024 Nov;
15(12):1245-1263.e10.
PMID: 39615483
T cells develop from hematopoietic progenitors in the thymus and protect against pathogens and cancer. However, the emergence of human T cell-competent blood progenitors and their subsequent specification to the...
3.
Cloarec-Ung F, Beaulieu J, Suthananthan A, Lehnertz B, Sauvageau G, Sheppard H, et al.
Elife
. 2024 Jun;
12.
PMID: 38829685
Precision gene editing in primary hematopoietic stem and progenitor cells (HSPCs) would facilitate both curative treatments for monogenic disorders as well as disease modelling. Precise efficiencies even with the CRISPR/Cas...
4.
Ibanez-Rios M, Narlis M, Hammond C, Knapp D
J Vis Exp
. 2023 Aug;
(197).
PMID: 37590518
The advancement of cell transplantation approaches requires model systems that allow an accurate assessment of transplanted cell functional potency. For the central nervous system, although xenotransplantation remains state-of-the-art, such models...
5.
Michaels Y, Edgar J, Major M, Castle E, Zimmerman C, Yin T, et al.
Sci Adv
. 2022 Aug;
8(34):eabn5522.
PMID: 36001668
T cells show tremendous efficacy as cellular therapeutics. However, obtaining primary T cells from human donors is expensive and variable. Pluripotent stem cells (PSCs) have the potential to provide a...
6.
Aalam S, Tang X, Song J, Ray U, Russell S, Weroha S, et al.
NAR Cancer
. 2022 Jul;
4(3):zcac022.
PMID: 35875052
A problematic feature of many human cancers is a lack of understanding of mechanisms controlling organ-specific patterns of metastasis, despite recent progress in identifying many mutations and transcriptional programs shown...
7.
Sadanandam A, Bopp T, Dixit S, Knapp D, Emperumal C, Vergidis P, et al.
Cell Death Discov
. 2020 Dec;
6(1):141.
PMID: 33293514
COVID-19 patients show heterogeneity in clinical presentation and outcomes that makes pandemic control and strategy difficult; optimizing management requires a systems biology approach of understanding the disease. Here we sought...
8.
Knapp D, Fulga T
Methods Mol Biol
. 2020 Sep;
2162:89-114.
PMID: 32926380
Transfer RNA (tRNA) and their associated production and processing machinery can be coopted as a versatile tool for the production of guide RNAs (gRNAs) for Cas9-based genome engineering. Using different...
9.
Kent D, Knapp D, Kannan N
Stem Cell Reports
. 2020 Jun;
15(1):1-5.
PMID: 32574555
COVID-19 has severely impacted laboratory research. Analysis of the International Society for Stem Cell Research (ISSCR) member survey has highlighted a particular impact on clinical trials and early-career investigators. The...
10.
Grants J, Wegrzyn J, Hui T, ONeill K, Shadbolt M, Knapp D, et al.
Blood
. 2020 May;
135(25):2235-2251.
PMID: 32384151
Aging is associated with significant changes in the hematopoietic system, including increased inflammation, impaired hematopoietic stem cell (HSC) function, and increased incidence of myeloid malignancy. Inflammation of aging ("inflammaging") has...