R Keith Humphries
Overview
Explore the profile of R Keith Humphries including associated specialties, affiliations and a list of published articles.
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Articles
126
Citations
5577
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Recent Articles
1.
Barbosa K, Deshpande A, Perales M, Xiang P, Murad R, Pramod A, et al.
Blood
. 2023 Dec;
143(8):697-712.
PMID: 38048593
Aberrant expression of stem cell-associated genes is a common feature in acute myeloid leukemia (AML) and is linked to leukemic self-renewal and therapy resistance. Using AF10-rearranged leukemia as a prototypical...
2.
Coulombe P, Cole G, Fentiman A, Parker J, Yung E, Bilenky M, et al.
Nat Commun
. 2023 Jul;
14(1):4537.
PMID: 37500618
Hematopoietic stem and progenitor cells (HSPCs) originate from an endothelial-to-hematopoietic transition (EHT) during embryogenesis. Characterization of early hemogenic endothelial (HE) cells is required to understand what drives hemogenic specification and...
3.
Xiang P, Yang X, Escano L, Dhillon I, Schneider E, Clemans-Gibbon J, et al.
Leukemia
. 2022 May;
36(8):1980-1989.
PMID: 35624144
Myeloid ecotropic virus insertion site 1 (MEIS1) is essential for normal hematopoiesis and is a critical factor in the pathogenesis of a large subset of acute myeloid leukemia (AML). Despite...
4.
Kloos A, Mintzas K, Winckler L, Gabdoulline R, Alwie Y, Jyotsana N, et al.
Leukemia
. 2021 Nov;
35(12):3629.
PMID: 34728793
No abstract available.
5.
Lee H, Lee G, Kim E, Kim H, Lee M, Humphries R, et al.
Haematologica
. 2021 Jan;
107(2):381-392.
PMID: 33440923
Chemoresistance of leukemic cells has largely been attributed to clonal evolution secondary to accumulating mutations. Here, we show that a subset of leukemic blasts in contact with the mesenchymal stroma...
6.
Kloos A, Mintzas K, Winckler L, Gabdoulline R, Alwie Y, Jyotsana N, et al.
Leukemia
. 2020 Jun;
34(11):2951-2963.
PMID: 32576961
To establish novel and effective treatment combinations for chronic myelomonocytic leukemia (CMML) preclinically, we hypothesized that supplementation of CMML cells with the human oncogene Meningioma 1 (MN1) promotes expansion and...
7.
Lin H, Rothe K, Chen M, Wu A, Babaian A, Yen R, et al.
Blood
. 2020 Apr;
136(5):596-609.
PMID: 32270193
Overcoming drug resistance and targeting cancer stem cells remain challenges for curative cancer treatment. To investigate the role of microRNAs (miRNAs) in regulating drug resistance and leukemic stem cell (LSC)...
8.
Schneider E, Pochert N, Ruess C, MacPhee L, Escano L, Miller C, et al.
Leukemia
. 2019 Nov;
34(5):1253-1265.
PMID: 31768018
MicroRNAs (miRNAs) are commonly deregulated in acute myeloid leukemia (AML), affecting critical genes not only through direct targeting, but also through modulation of downstream effectors. Homeobox (Hox) genes balance self-renewal,...
9.
Cardin S, Bilodeau M, Roussy M, Aubert L, Milan T, Jouan L, et al.
Blood Adv
. 2019 Nov;
3(21):3307-3321.
PMID: 31698461
Acute megakaryoblastic leukemia (AMKL) represents ∼10% of pediatric acute myeloid leukemia cases and typically affects young children (<3 years of age). It remains plagued with extremely poor treatment outcomes (<40%...
10.
Kusakabe M, Sun A, Tyshchenko K, Wong R, Nanda A, Shanna C, et al.
Nat Commun
. 2019 Jul;
10(1):2913.
PMID: 31266935
Mechanistic studies in human cancer have relied heavily on cell lines and mouse models, but are limited by in vitro adaptation and species context issues, respectively. More recent efforts have...