David J Cousins
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Explore the profile of David J Cousins including associated specialties, affiliations and a list of published articles.
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36
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1338
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Recent Articles
21.
Beale J, Jayaraman A, Jackson D, Macintyre J, Edwards M, Walton R, et al.
Sci Transl Med
. 2014 Oct;
6(256):256ra134.
PMID: 25273095
Rhinoviruses (RVs), which are the most common cause of virally induced asthma exacerbations, account for much of the burden of asthma in terms of morbidity, mortality, and associated cost. Interleukin-25...
22.
Brough H, Cousins D, Munteanu A, Wong Y, Sudra A, Makinson K, et al.
J Allergy Clin Immunol
. 2014 Aug;
134(6):1329-1338.e10.
PMID: 25112699
Background: Differentiation between patients with peanut allergy (PA) and those with peanut sensitization (PS) who tolerate peanut but have peanut-specific IgE, positive skin prick test responses, or both represents a...
23.
Distinct conformations of the chemokine receptor CCR4 with implications for its targeting in allergy
Viney J, Andrew D, Phillips R, Meiser A, Patel P, Lennartz-Walker M, et al.
J Immunol
. 2014 Feb;
192(7):3419-27.
PMID: 24563252
CC chemokine receptor 4 (CCR4) is expressed by Th2 and regulatory T cells and directs their migration along gradients of the chemokines CCL17 and CCL22. Both chemokines and receptor are...
24.
Parmentier C, Fuerst E, McDonald J, Bowen H, Lee T, Pease J, et al.
J Allergy Clin Immunol
. 2012 Mar;
129(4):1136-42.
PMID: 22391114
Background: Allergic asthma is characterized by reversible airway obstruction and bronchial hyperresponsiveness associated with T(H)2 cell-mediated inflammation. Cysteinyl leukotrienes (CysLTs) are potent lipid mediators involved in bronchoconstriction, mucus secretion, and...
25.
Rani A, Afzali B, Kelly A, Tewolde-Berhan L, Hackett M, Kanhere A, et al.
J Immunol
. 2011 Aug;
187(7):3721-9.
PMID: 21876034
Blockade of IL-2R with humanized anti-CD25 Abs, such as daclizumab, inhibits Th2 responses in human T cells. Recent murine studies have shown that IL-2 also plays a significant role in...
26.
Mahn K, Hirst S, Ying S, Holt M, Lavender P, Ojo O, et al.
Proc Natl Acad Sci U S A
. 2009 Jun;
106(26):10775-80.
PMID: 19541629
Phenotypic modulation of airway smooth muscle (ASM) is an important feature of airway remodeling in asthma that is characterized by enhanced proliferation and secretion of pro-inflammatory chemokines. These activities are...
27.
Sandig H, McDonald J, Gilmour J, Arno M, Lee T, Cousins D
J Allergy Clin Immunol
. 2009 Jun;
124(3):528-35, 535.e1-5.
PMID: 19541353
Background: T(H)1 cell-mediated immunity is essential for host defense against a variety of intracellular pathogens, such as mycobacteria, salmonella, and Leishmania species. A major T(H)1-mediated effector mechanism involves the IFN-gamma-induced...
28.
Santangelo S, Cousins D, Winkelmann N, Triantaphyllopoulos K, Staynov D
Chromosome Res
. 2009 Jun;
17(4):485-96.
PMID: 19521787
Human T(H)2 cell differentiation results in the selective demethylation of several specific CpG dinucleotides in the IL-4 and IL-13 genes, which are expressed in activated T(H)2, but not T(H)1, cells....
29.
Urry Z, Xystrakis E, Richards D, McDonald J, Sattar Z, Cousins D, et al.
J Clin Invest
. 2009 Jan;
119(2):387-98.
PMID: 19139565
Signaling through the TLR family of molecular pattern recognition receptors has been implicated in the induction of innate and adaptive immune responses. A role for TLR signaling in the maintenance...
30.
Cousins D, McDonald J, Lee T
J Allergy Clin Immunol
. 2008 Apr;
121(4):803-9.
PMID: 18395546
The inflammatory response observed in allergic disease involves multiple cell types but is orchestrated in part by the T(H)2 cytokines IL-4, IL-5, and IL-13. In recent years, the transcription factors...