David J Cousins
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Explore the profile of David J Cousins including associated specialties, affiliations and a list of published articles.
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1338
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Recent Articles
11.
Cousins D
Sci Transl Med
. 2017 Aug;
9(401).
PMID: 28768801
A new proinflammatory subtype of antigen-specific T2 cell that expresses CD161 emerges as the pathogenic cell type in allergic disease and is deleted during allergen-specific immunotherapy (Wambre , this issue).
12.
Wright A, Weston C, Rana B, Brightling C, Cousins D
J Allergy Clin Immunol
. 2017 May;
140(5):1430-1433.e4.
PMID: 28502824
No abstract available.
13.
Dhariwal J, Cameron A, Trujillo-Torralbo M, Del Rosario A, Bakhsoliani E, Paulsen M, et al.
Am J Respir Crit Care Med
. 2017 Jan;
195(12):1586-1596.
PMID: 28085492
Rationale: Newly characterized type 2 innate lymphoid cells (ILC2s) display potent type 2 effector functionality; however, their contribution to allergic airways inflammation and asthma is poorly understood. Mucosal biopsy used...
14.
Slovick A, Douiri A, Muir R, Guerra A, Tsioulos K, Hay E, et al.
J Allergy Clin Immunol
. 2016 Oct;
139(6):1830-1839.e13.
PMID: 27773851
Background: Repeated low-dose grass pollen intradermal allergen injection suppresses allergen-induced cutaneous late-phase responses comparably with conventional subcutaneous and sublingual immunotherapy. Objective: We sought to evaluate the efficacy and safety of...
15.
Hertweck A, Evans C, Eskandarpour M, Lau J, Oleinika K, Jackson I, et al.
Cell Rep
. 2016 Jun;
15(12):2756-70.
PMID: 27292648
The transcription factor T-bet directs Th1 cell differentiation, but the molecular mechanisms that underlie this lineage-specific gene regulation are not completely understood. Here, we show that T-bet acts through enhancers...
16.
Foster H, Fuerst E, Branchett W, Lee T, Cousins D, Woszczek G
Sci Rep
. 2016 Feb;
6:20461.
PMID: 26830450
Leukotriene E4 (LTE4) the most stable of the cysteinyl leukotrienes (cysLTs) binds poorly to classical type 1 (CysLT1) and 2 (CysLT2) receptors although it induces potent responses in human airways...
17.
Lam E, Kariyawasam H, Rana B, Durham S, McKenzie A, Powell N, et al.
J Allergy Clin Immunol
. 2015 Dec;
137(5):1514-24.
PMID: 26684290
Background: Chronic rhinosinusitis with nasal polyposis (CRSwNP) in Western countries is characterized by eosinophilia, IgE production, and TH2 cytokine expression. Type 2 innate lymphoid cells from polyps produce IL-5 and...
18.
Salimi M, Xue L, Jolin H, Hardman C, Cousins D, McKenzie A, et al.
J Immunol
. 2015 Nov;
196(1):45-54.
PMID: 26582946
Group 2 innate lymphoid cells (ILC2) are important in effector functions for eliciting allergic inflammation, parasite defense, epithelial repair, and lipid homeostasis. ILC2 lack rearranged Ag-specific receptors, and although many...
19.
Pfeffer P, Chen Y, Woszczek G, Matthews N, Chevretton E, Gupta A, et al.
J Allergy Clin Immunol
. 2014 Dec;
135(3):824-7.e3.
PMID: 25457999
No abstract available.
20.
Jackson D, Makrinioti H, Rana B, Shamji B, Trujillo-Torralbo M, Footitt J, et al.
Am J Respir Crit Care Med
. 2014 Oct;
190(12):1373-82.
PMID: 25350863
Rationale: Rhinoviruses are the major cause of asthma exacerbations; however, its underlying mechanisms are poorly understood. We hypothesized that the epithelial cell-derived cytokine IL-33 plays a central role in exacerbation...