David I Rhodes
Overview
Explore the profile of David I Rhodes including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
211
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Recent Articles
11.
Coghlan D, Bremner J, Keller P, Pyne S, David D, Somphol K, et al.
Bioorg Med Chem
. 2011 May;
19(11):3549-57.
PMID: 21550811
As part of a programme investigating antibacterial cyclic macrocycles containing a cationic amino acid with an internal aromatic hydrophobic scaffold, we previously reported a macrocycle anchored at the 3,3'-positions of...
12.
Wielens J, Headey S, Deadman J, Rhodes D, Le G, Parker M, et al.
ChemMedChem
. 2011 Jan;
6(2):258-61.
PMID: 21275048
No abstract available.
13.
Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: azoles: effective metal chelators
Le G, Vandegraaff N, Rhodes D, Jones E, Coates J, Thienthong N, et al.
Bioorg Med Chem Lett
. 2010 Aug;
20(19):5909-12.
PMID: 20727753
Synthesis of a diverse set of azoles and their utilizations as an amide isostere in the design of HIV integrase inhibitors is described. The Letter identified thiazole, oxazole, and imidazole...
14.
Jones E, Vandegraaff N, Le G, Choi N, Issa W, Macfarlane K, et al.
Bioorg Med Chem Lett
. 2010 Aug;
20(19):5913-7.
PMID: 20727748
HIV integrase inhibitors based on a novel bicyclic pyrimidinone core is presented. Nine variations of the core scaffold are evaluated leading to optimization of the 6:6 core giving compound 48...
15.
Le G, Vandegraaff N, Rhodes D, Jones E, Coates J, Lu L, et al.
Bioorg Med Chem Lett
. 2010 Aug;
20(17):5013-8.
PMID: 20685117
A series of novel HIV integrase inhibitors active against rategravir resistant strains are reported. Initial SAR studies revealed that activities against wild-type virus were successfully maintained at single digit nanomolar...
16.
Bremner J, Keller P, Pyne S, Boyle T, Brkic Z, Morgan J, et al.
Bioorg Med Chem
. 2010 Jul;
18(13):4793-800.
PMID: 20627739
A compact synthesis of 15 new binaphthyl-based dicationic tripeptoids and one biphenyl based dicationic tripeptoid is described. Fourteen of these tripeptoids resulted from variation of the C-2' ether substituent of...
17.
Bremner J, Keller P, Pyne S, Boyle T, Brkic Z, David D, et al.
Bioorg Med Chem
. 2010 Mar;
18(7):2611-20.
PMID: 20236828
An efficient synthesis of 29 new binaphthyl-based neutral, and mono- and di-cationic, peptoids is described. Some of these compounds had antibacterial activities with MIC values of 1.9-3.9microg/mL against Staphylococcus aureus....
18.
Wielens J, Headey S, Jeevarajah D, Rhodes D, Deadman J, Chalmers D, et al.
FEBS Lett
. 2010 Mar;
584(8):1455-62.
PMID: 20227411
HIV integrase (IN) is an essential enzyme in HIV replication and an important target for drug design. IN has been shown to interact with a number of cellular and viral...
19.
Bremner J, Keller P, Pyne S, Boyle T, Brkic Z, David D, et al.
Angew Chem Int Ed Engl
. 2009 Dec;
49(3):537-40.
PMID: 20014083
No abstract available.
20.
Garas A, Bremner J, Coates J, Deadman J, Keller P, Pyne S, et al.
Bioorg Med Chem Lett
. 2009 May;
19(11):3010-3.
PMID: 19409783
An efficient synthesis of four new acyclic and four new cyclic binaphthyl-based cationic peptoids is described. These compounds had anti-bacterial activities with MIC values of 4-62 microg/mL against Staphylococcus aureus.