Stephen G Pyne
Overview
Explore the profile of Stephen G Pyne including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
154
Citations
692
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Ali S, McCosker P, Willis A, Pyne S, Richardson C, Bremner J, et al.
Molecules
. 2024 Sep;
29(17).
PMID: 39275089
The reaction of indigo with two equivalents of the electrophile ethyl bromoacetate with caesium carbonate as a base result in the formation of structurally complex polyheterocyclics, including a fused spiroimidazole...
2.
Chao C, Pham Q, Richardson C, Pyne S, Hyland C
J Org Chem
. 2024 Aug;
89(18):13744-13755.
PMID: 39206628
Diastereoselective Pd-catalyzed (3+2) and (4+2) cycloaddition reactions of sulfamidate imine-derived 1-azadienes with zwitterionic N-dipoles derived from 1-tosyl-2-vinylaziridine and 4-vinylbenzoxazinone have been developed. These reactions provide highly functionalized azaspirocycles featuring three...
3.
Cun W, Keller P, Pyne S
Microorganisms
. 2024 Jun;
12(6).
PMID: 38930588
is a Gram-positive, spore-forming anaerobic bacterial pathogen that causes severe gastrointestinal infection in humans. This review provides background information on infection and the pathogenesis and toxigenicity of . The risk...
4.
Cun W, Bate C, Srikhanta Y, Hutton M, Webb C, Revitt-Mills S, et al.
J Med Chem
. 2023 Dec;
67(1):450-466.
PMID: 38112278
With the aim of discovering small molecule inhibitors of the sporulation process in , we prepared a series of C-7 α-(4-substituted-1-1,2,3-triazol-1-yl)acetamide analogues of cefotetan, a known inhibitor of the sporulation-specific...
5.
Cun W, Keller P, Pyne S
Molecules
. 2023 Nov;
28(21).
PMID: 37959756
The aim of this project was to develop a synthetic protocol for the preparation of a cephamycin scaffold that would readily allow the synthesis of its analogues with variations at...
6.
Tague A, Pham Q, Richardson C, Pyne S, Hyland C
Chemistry
. 2023 Sep;
29(69):e202302406.
PMID: 37718289
A formal palladium-catalyzed decarboxylative (4+2) cycloaddition reaction between 4-vinylbenzoxazinanones and 2-nitro-1,3-enynes has been developed to produce highly valuable, densely functionalized tetrahydroquinolines in moderate to excellent yields with high diastereoselectivity under...
7.
Chao C, Pyne S, Hyland C, Lee R
Chem Asian J
. 2023 Sep;
18(21):e202300724.
PMID: 37712336
Density functional theory (DFT) has provided a detailed mechanistic picture for the redox neutral nickel(II)-catalyzed arylative cyclization reactions of a tethered allene-ketone with arylboronic acids. A mechanistic rationale for the...
8.
Chevis P, Chao C, Richardson C, Hyland C, Lee R, Pyne S
Chemistry
. 2023 Jul;
29(53):e202301701.
PMID: 37414734
The crotylation reactions of chiral α-F, α-OBz and α-OH aldehydes under Petasis-borono-Mannich conditions using (E)- or (Z)-crotylboronates and primary amines resulted in γ-addition products in high dr and high er....
9.
Pham Q, Tague A, Richardson C, Gardiner M, Pyne S, Hyland C
Chem Sci
. 2023 May;
14(18):4893-4900.
PMID: 37181759
An enantio- and diastereoselective Pd-catalysed (3 + 2) cycloaddition of bis(trifluoroethyl) 2-vinyl-cyclopropane-1,1-dicarboxylate (VCP) with cyclic sulfamidate imine-derived 1-azadienes (SDAs) has been developed. These reactions provide highly functionalized spiroheterocycles having three...
10.
Byatt B, Kato A, Pyne S
J Nat Prod
. 2023 May;
86(5):1261-1273.
PMID: 37125736
The 10 glyphaeaside alkaloids isolated from the roots of were originally purported as piperidine-based 1--alkylated iminosugars, with the A-, B-, and C-type glyphaeasides bearing l-DFJ, DGJ, and DNJ ring configurations,...