David Harrison
Overview
Explore the profile of David Harrison including associated specialties, affiliations and a list of published articles.
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151
Citations
7627
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Recent Articles
1.
Kapadia C, Williams N, Dawson K, Watson C, Yousefzadeh M, Le D, et al.
Nature
. 2025 Mar;
PMID: 40044850
Haematopoietic stem cells maintain blood production throughout life. Although extensively characterized using the laboratory mouse, little is known about clonal selection and population dynamics of the haematopoietic stem cell pool...
2.
Williamson E, Tazare J, Bhaskaran K, Walker A, McDonald H, Tomlinson L, et al.
Wellcome Open Res
. 2025 Feb;
5:243.
PMID: 39931522
On March 11th 2020, the World Health Organization characterised COVID-19 as a pandemic. Responses to containing the spread of the virus have relied heavily on policies involving restricting contact between...
3.
Aweid B, Parnis N, Harrison D
BMC Med Educ
. 2025 Feb;
25(1):173.
PMID: 39901254
Background: Physician Associates have recently been introduced to the UK healthcare workforce. Their curriculum includes important topics in Geriatric medicine. As they undertake a 2-year intensive postgraduate course we wanted...
4.
Harrison D
J Med Chem
. 2024 Dec;
67(23):20776-20779.
PMID: 39621542
The NLRP3 inflammasome has attracted much interest as a drug target; however, many of the first wave of inhibitors were derived from a single aryl sulfonylurea starting point. The physicochemical...
5.
Coylewright M, Harrison D, Deb B, Streed Jr C
Interv Cardiol Clin
. 2024 Nov;
14(1):87-96.
PMID: 39537291
Transgender and gender diverse patients undergoing cardiac procedures require unique considerations to ensure the delivery of respectful, safe, and high-value health care. There are several issues for which practicing clinicians...
6.
Kapadia C, Williams N, Dawson K, Watson C, Yousefzadeh M, Le D, et al.
bioRxiv
. 2024 Sep;
PMID: 39345649
Haematopoietic stem cells maintain blood production throughout life. While extensively characterised using the laboratory mouse, little is known about how the population is sustained and evolves with age. We isolated...
7.
Doedens J, Diamond C, Harrison D, Bock M, Clarke N, Watt A, et al.
Biochem Pharmacol
. 2024 Jul;
227:116455.
PMID: 39069136
NT-0796 is an ester prodrug which is metabolized by carboxylesterase-1 (CES1) to yield the carboxylic acid NDT-19795, an inhibitor of the NLR family pyrin domain-containing protein 3 (NLRP3) inflammasome. When...
8.
Swan L, Windram J, Burchill L, Ladak L, Reardon L, Fernandez B, et al.
JACC Adv
. 2024 Jun;
2(10):100716.
PMID: 38938496
As health care outcomes improve the priority for those living with adult congenital heart disease have changed to a more holistic focus on quality of life and well-being. Although health...
9.
Doedens J, Smolak P, Nguyen M, Wescott H, Diamond C, Schooley K, et al.
ACS Pharmacol Transl Sci
. 2024 May;
7(5):1438-1456.
PMID: 38751618
Interleukin (IL)-1β is an apex proinflammatory cytokine produced in response to tissue injury and infection. The output of IL-1β from monocytes and macrophages is regulated not only by transcription and...
10.
Thornton P, Reader V, Digby Z, Smolak P, Lindsay N, Harrison D, et al.
J Pharmacol Exp Ther
. 2024 Feb;
388(3):813-826.
PMID: 38336379
Systemic and cerebral inflammatory responses are implicated in the pathogenesis of obesity and associated metabolic impairment. While the NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome has been linked...