Peter D Yurchenco
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Explore the profile of Peter D Yurchenco including associated specialties, affiliations and a list of published articles.
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53
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3576
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Recent Articles
1.
Yurchenco P, Kulczyk A
J Biol Chem
. 2024 Jun;
300(7):107429.
PMID: 38825010
Polymerizing laminins are multi-domain basement membrane (BM) glycoproteins that self-assemble into cell-anchored planar lattices to establish the initial BM scaffold. Nidogens, collagen-IV and proteoglycans then bind to the scaffold at...
2.
McKee K, Yurchenco P
Matrix Biol
. 2023 Mar;
118:1-15.
PMID: 36878377
Null mutations of the Lama2-gene cause a severe congenital muscular dystrophy and associated neuropathy. In the absence of laminin-α2 (Lmα2) there is a compensatory replacement by Lmα4, a subunit that...
3.
Kulczyk A, McKee K, Zhang X, Bizukojc I, Yu Y, Yurchenco P
Nat Commun
. 2023 Jan;
14(1):317.
PMID: 36658135
Laminin polymerization is the major step in basement membranes assembly. Its failures cause laminin N-terminal domain lamininopathies including Pierson syndrome. We have employed cryo-electron microscopy to determine a 3.7 Å...
4.
Ruan J, McKee K, Yurchenco P, Yao Y
Fluids Barriers CNS
. 2022 Dec;
19(1):97.
PMID: 36463265
Background: Unlike other proteins that exhibit a diffusion pattern after intracerebral injection, laminin displays a vascular pattern. It remains unclear if this unique vascular pattern is caused by laminin-receptor interaction...
5.
McKee K, Yurchenco P
JCI Insight
. 2022 May;
7(13).
PMID: 35639486
LAMA2 deficiency, resulting from a defective or absent laminin α2 subunit, is a common cause of congenital muscular dystrophy. It is characterized by muscle weakness from myofiber degeneration and neuropathy...
6.
McKee K, Hohenester E, Aleksandrova M, Yurchenco P
Matrix Biol
. 2021 May;
98:49-63.
PMID: 34029691
Laminin polymerization is a key step of basement membrane assembly that depends on the binding of α, β and γ N-terminal LN domains to form a polymer node. Nodal assembly...
7.
Funk S, Bayer R, McKee K, Okada K, Nishimune H, Yurchenco P, et al.
Kidney Int
. 2020 May;
98(1):133-146.
PMID: 32456966
The importance of the glomerular basement membrane (GBM) in glomerular filtration is underscored by the manifestations of Alport and Pierson syndromes, caused by defects in type IV collagen α3α4α5 and...
8.
A mutation affecting laminin alpha 5 polymerisation gives rise to a syndromic developmental disorder
Jones L, Lam R, McKee K, Aleksandrova M, Dowling J, Alexander S, et al.
Development
. 2020 May;
147(21).
PMID: 32439764
Laminin alpha 5 (LAMA5) is a member of a large family of proteins that trimerise and then polymerise to form a central component of all basement membranes. Consequently, the protein...
9.
Yurchenco P, McKee K
Front Mol Neurosci
. 2020 Jan;
12:305.
PMID: 31920536
An understanding of basement membrane (BM) assembly at a molecular level provides a foundation with which to develop repair strategies for diseases with defects of BM structure. As currently understood,...
10.
McKee K, Aleksandrova M, Yurchenco P
Matrix Biol
. 2018 Feb;
67:32-46.
PMID: 29408412
Laminin polymerization is a key step of basement membrane self-assembly that depends on the binding of the three different N-terminal globular LN domains. Several mutations in the LN domains cause...