David Fernandez-Antoran
Overview
Explore the profile of David Fernandez-Antoran including associated specialties, affiliations and a list of published articles.
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8
Citations
172
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Recent Articles
1.
Herms A, Fernandez-Antoran D, Alcolea M, Kalogeropoulou A, Banerjee U, Piedrafita G, et al.
Nat Genet
. 2024 Sep;
56(10):2158-2173.
PMID: 39313617
Aging epithelia are colonized by somatic mutations, which are subjected to selection influenced by intrinsic and extrinsic factors. The lack of suitable culture systems has slowed the study of this...
2.
Herms A, Colom B, Piedrafita G, Kalogeropoulou A, Banerjee U, King C, et al.
Nat Genet
. 2024 Aug;
56(10):2144-2157.
PMID: 39169259
Oncogenic PIK3CA mutations generate large clones in aging human esophagus. Here we investigate the behavior of Pik3ca mutant clones in the normal esophageal epithelium of transgenic mice. Expression of a...
3.
Hoo R, Ruiz-Morales E, Kelava I, Rawat M, Mazzeo C, Tuck E, et al.
Cell Syst
. 2024 May;
15(5):425-444.e9.
PMID: 38703772
The placenta is a selective maternal-fetal barrier that provides nourishment and protection from infections. However, certain pathogens can attach to and even cross the placenta, causing pregnancy complications with potential...
4.
Murai K, Dentro S, Ong S, Sood R, Fernandez-Antoran D, Herms A, et al.
Nat Commun
. 2022 Oct;
13(1):6206.
PMID: 36266286
Aging normal human oesophagus accumulates TP53 mutant clones. These are the origin of most oesophageal squamous carcinomas, in which biallelic TP53 disruption is almost universal. However, how p53 mutant clones...
5.
Fowler J, King C, Bryant C, Hall M, Sood R, Ong S, et al.
Cancer Discov
. 2020 Oct;
11(2):340-361.
PMID: 33087317
Skin cancer risk varies substantially across the body, yet how this relates to the mutations found in normal skin is unknown. Here we mapped mutant clones in skin from high-...
6.
Piedrafita G, Kostiou V, Wabik A, Colom B, Fernandez-Antoran D, Herms A, et al.
Nat Commun
. 2020 Mar;
11(1):1429.
PMID: 32188860
In adult skin epidermis and the epithelium lining the esophagus cells are constantly shed from the tissue surface and replaced by cell division. Tracking genetically labelled cells in transgenic mice...
7.
Fernandez-Antoran D, Piedrafita G, Murai K, Ong S, Herms A, Frezza C, et al.
Cell Stem Cell
. 2019 Jul;
25(3):329-341.e6.
PMID: 31327664
As humans age, normal tissues, such as the esophageal epithelium, become a patchwork of mutant clones. Some mutations are under positive selection, conferring a competitive advantage over wild-type cells. We...
8.
Perez-Olivares M, Trento A, Rodriguez-Acebes S, Gonzalez-Acosta D, Fernandez-Antoran D, Roman-Garcia S, et al.
EMBO Rep
. 2018 Aug;
19(10).
PMID: 30126925
The Myc family of oncogenic transcription factors regulates myriad cellular functions. Myc proteins contain a basic region/helix-loop-helix/leucine zipper domain that mediates DNA binding and heterodimerization with its partner Max. Among...