Albert Herms
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Explore the profile of Albert Herms including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
742
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0
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Recent Articles
1.
Herms A, Fernandez-Antoran D, Alcolea M, Kalogeropoulou A, Banerjee U, Piedrafita G, et al.
Nat Genet
. 2024 Sep;
56(10):2158-2173.
PMID: 39313617
Aging epithelia are colonized by somatic mutations, which are subjected to selection influenced by intrinsic and extrinsic factors. The lack of suitable culture systems has slowed the study of this...
2.
Herms A, Colom B, Piedrafita G, Kalogeropoulou A, Banerjee U, King C, et al.
Nat Genet
. 2024 Aug;
56(10):2144-2157.
PMID: 39169259
Oncogenic PIK3CA mutations generate large clones in aging human esophagus. Here we investigate the behavior of Pik3ca mutant clones in the normal esophageal epithelium of transgenic mice. Expression of a...
3.
Abby E, Dentro S, Hall M, Fowler J, Ong S, Sood R, et al.
Nat Genet
. 2023 Jan;
55(2):232-245.
PMID: 36658434
NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal expansion but impede carcinogenesis. Here...
4.
5.
Murai K, Dentro S, Ong S, Sood R, Fernandez-Antoran D, Herms A, et al.
Nat Commun
. 2022 Oct;
13(1):6206.
PMID: 36266286
Aging normal human oesophagus accumulates TP53 mutant clones. These are the origin of most oesophageal squamous carcinomas, in which biallelic TP53 disruption is almost universal. However, how p53 mutant clones...
6.
Colom B, Alcolea M, Piedrafita G, Hall M, Wabik A, Dentro S, et al.
Nat Genet
. 2020 May;
52(6):604-614.
PMID: 32424351
During aging, progenitor cells acquire mutations, which may generate clones that colonize the surrounding tissue. By middle age, normal human tissues, including the esophageal epithelium (EE), become a patchwork of...
7.
Piedrafita G, Kostiou V, Wabik A, Colom B, Fernandez-Antoran D, Herms A, et al.
Nat Commun
. 2020 Mar;
11(1):1429.
PMID: 32188860
In adult skin epidermis and the epithelium lining the esophagus cells are constantly shed from the tissue surface and replaced by cell division. Tracking genetically labelled cells in transgenic mice...
8.
Fernandez-Antoran D, Piedrafita G, Murai K, Ong S, Herms A, Frezza C, et al.
Cell Stem Cell
. 2019 Jul;
25(3):329-341.e6.
PMID: 31327664
As humans age, normal tissues, such as the esophageal epithelium, become a patchwork of mutant clones. Some mutations are under positive selection, conferring a competitive advantage over wild-type cells. We...
9.
Herms A, Bosch M, Reddy B, Schieber N, Fajardo A, Ruperez C, et al.
Nat Commun
. 2015 May;
6:7176.
PMID: 26013497
Lipid droplets (LDs) are intracellular organelles that provide fatty acids (FAs) to cellular processes including synthesis of membranes and production of metabolic energy. While known to move bidirectionally along microtubules...
10.
Kassan A, Herms A, Fernandez-Vidal A, Bosch M, Schieber N, Reddy B, et al.
J Cell Biol
. 2013 Dec;
203(6):985-1001.
PMID: 24368806
Control of lipid droplet (LD) nucleation and copy number are critical, yet poorly understood, processes. We use model peptides that shift from the endoplasmic reticulum (ER) to LDs in response...