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David Diemert

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Articles 33
Citations 7149
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Recent Articles
1.
Yamey G, McDade K, Anderson R, Bartsch S, Bottazzi M, Diemert D, et al.
Vaccine . 2024 Nov; :126020. PMID: 39592316
Schistosomiasis is caused by parasitic flatworms (Schistosoma). The disease in humans can be caused by seven different species of Schistosoma: S. mansoni, S. japonicum, S. haematobium, S. malayensis, S. mekongi,...
2.
deCamp A, Corcoran M, Fulp W, Willis J, Cottrell C, Bader D, et al.
NPJ Vaccines . 2024 Mar; 9(1):58. PMID: 38467663
Vaccine priming immunogens that activate germline precursors for broadly neutralizing antibodies (bnAbs) have promise for development of precision vaccines against major human pathogens. In a clinical trial of the eOD-GT8...
3.
Puchner K, Bottazzi M, Periago V, Grobusch M, Maizels R, McCarthy J, et al.
Vaccine . 2023 Oct; 42(19S1):S25-S41. PMID: 37863671
Hookworm, a parasitic infection, retains a considerable burden of disease, affecting the most underprivileged segments of the general population in endemic countries and remains one of the leading causes of...
4.
Scholte L, Leggat D, Cohen K, Hoeweler L, Erwin G, Rahaman F, et al.
STAR Protoc . 2023 Sep; 4(4):102576. PMID: 37733596
The lymph node (LN) is a critical biological site for immune maturation after vaccination as it includes several cell populations critical for priming the antibody response. Here, we present a...
5.
de Bruyn G, Wang J, Purvis A, Ruiz M, Adhikarla H, Alvi S, et al.
EClinicalMedicine . 2023 Aug; 62:102109. PMID: 37533419
Background: In a parallel-group, international, phase 3 study (ClinicalTrials.govNCT04762680), we evaluated prototype (D614) and Beta (B.1.351) variant recombinant spike protein booster vaccines with AS03-adjuvant (CoV2 preS dTM-AS03). Methods: Adults, previously...
6.
Cohen K, De Rosa S, Fulp W, deCamp A, Fiore-Gartland A, Mahoney C, et al.
Sci Transl Med . 2023 May; 15(697):eadf3309. PMID: 37224227
The engineered outer domain germline targeting version 8 (eOD-GT8) 60-mer nanoparticle was designed to prime VRC01-class HIV-specific B cells that would need to be matured, through additional heterologous immunizations, into...
7.
Branche A, Rouphael N, Diemert D, Falsey A, Losada C, Baden L, et al.
Res Sq . 2023 May; PMID: 37205592
Vaccine protection against COVID-19 wanes over time and has been impacted by the emergence of new variants with increasing escape of neutralization. The COVID-19 Variant Immunologic Landscape (COVAIL) randomized clinical...
8.
deCamp A, Corcoran M, Fulp W, Willis J, Cottrell C, Bader D, et al.
medRxiv . 2023 Mar; PMID: 36993183
One-sentence Summary: Human genetic variation can modulate the strength of vaccine-induced broadly neutralizing antibody precursor B cell responses.
9.
Garofano K, Rashid K, Smith M, Brantner C, Suwunnakorn S, Diemert D, et al.
Sci Rep . 2023 Feb; 13(1):2864. PMID: 36806315
Platelets play a crucial role in cancer and thrombosis. However, the receptor-ligand repertoire mediating prostate cancer (PCa) cell-platelet interactions and ensuing consequences have not been fully elucidated. Microvilli emanating from...
10.
Leggat D, Cohen K, Willis J, Fulp W, deCamp A, Kalyuzhniy O, et al.
Science . 2022 Dec; 378(6623):eadd6502. PMID: 36454825
Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare bnAb-precursor B...