David Diemert
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Explore the profile of David Diemert including associated specialties, affiliations and a list of published articles.
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33
Citations
7149
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Recent Articles
11.
Betouke Ongwe M, Mouwenda Y, Stam K, Kremsner P, Lell B, Diemert D, et al.
PLoS One
. 2022 Sep;
17(9):e0275013.
PMID: 36155987
Metabolomics provides a powerful tool to study physiological changes in response to various perturbations such as vaccination. We explored whether metabolomic changes could be seen after vaccination in a phase...
12.
Sridhar S, Joaquin A, Bonaparte M, Bueso A, Chabanon A, Chen A, et al.
Lancet Infect Dis
. 2022 Jan;
22(5):636-648.
PMID: 35090638
Background: We evaluated our SARS-CoV-2 prefusion spike recombinant protein vaccine (CoV2 preS dTM) with different adjuvants, unadjuvanted, and in a one-injection and two-injection dosing schedule in a previous phase 1-2...
13.
Adewale B, Heintz J, Pastore C, Rossi H, Hung L, Rahman N, et al.
PLoS Negl Trop Dis
. 2021 Oct;
15(10):e0009550.
PMID: 34662329
Helminth infections, including hookworms and Schistosomes, can cause severe disability and death. Infection management and control would benefit from identification of biomarkers for early detection and prognosis. While animal models...
14.
Pritchard D, Diemert D, Bottazzi M, Hawdon J, Correa-Oliveira R, Bethony J
Curr Top Microbiol Immunol
. 2021 Jul;
445:367-377.
PMID: 34328562
In this chapter, we describe the scientific, technical, clinical and regulatory aspects of establishing a controlled human hookworm infection (CHHI) model in non-endemic and endemic geographical regions, to facilitate a...
15.
Garofano K, Park C, Alarcon C, Avitia J, Barbour A, Diemert D, et al.
Clin Pharmacol Ther
. 2021 Jul;
110(3):702-713.
PMID: 34255863
The African American (AA) population displays a 1.6 to 3-fold higher incidence of thrombosis and stroke mortality compared with European Americans (EAs). Current antiplatelet therapies target the ADP-mediated signaling pathway,...
16.
Li G, Hoeweler L, Keegan B, Peng J, Scholte L, Hotez P, et al.
Vaccine X
. 2021 Jun;
8:100100.
PMID: 34169270
Introduction: As a primary stability-indicating parameter, potency should be strategically evaluated during each phase of vaccine development. Herein, we present potency testing during the early clinical development of the ()...
17.
Baden L, El Sahly H, Essink B, Kotloff K, Frey S, Novak R, et al.
N Engl J Med
. 2020 Dec;
384(5):403-416.
PMID: 33378609
Background: Vaccines are needed to prevent coronavirus disease 2019 (Covid-19) and to protect persons who are at high risk for complications. The mRNA-1273 vaccine is a lipid nanoparticle-encapsulated mRNA-based vaccine...
18.
Diemert D, Campbell D, Brelsford J, Leasure C, Li G, Peng J, et al.
Open Forum Infect Dis
. 2018 May;
5(5):ofy083.
PMID: 29780848
Background: Controlled human hookworm infection (CHHI) is a central component of a proposed hookworm vaccination-challenge model (HVCM) to test the efficacy of candidate vaccines. Critical to CHHI is the manufacture...
19.
Brelsford J, Plieskatt J, Yakovleva A, Jariwala A, Keegan B, Peng J, et al.
PLoS Negl Trop Dis
. 2017 Feb;
11(2):e0005385.
PMID: 28192438
A new generation of vaccines for the neglected tropical diseases (NTDs) have now advanced into clinical development, with the Na-GST-1/Alhydrogel Hookworm Vaccine already being tested in Phase 1 studies in...
20.
Loukas A, Hotez P, Diemert D, Yazdanbakhsh M, McCarthy J, Correa-Oliveira R, et al.
Nat Rev Dis Primers
. 2016 Dec;
2:16088.
PMID: 27929101
Hookworms are soil-transmitted nematode parasites that can reside for many years in the small intestine of their human hosts; Necator americanus is the predominant infecting species. Adult worms feed on...