David D Boehr
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Explore the profile of David D Boehr including associated specialties, affiliations and a list of published articles.
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56
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2265
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Recent Articles
11.
DAmico R, Murray A, Boehr D
Bioessays
. 2020 Jul;
42(9):e2000092.
PMID: 32720327
A general framework by which dynamic interactions within a protein will promote the necessary series of structural changes, or "conformational cycle," required for function is proposed. It is suggested that...
12.
Gorman S, Winston D, Sahu D, Boehr D
Biochemistry
. 2020 Jun;
59(27):2528-2540.
PMID: 32538627
Allosteric regulation is important in many biological processes, including cell signaling, gene regulation, and metabolism. chorismate mutase (ScCM) is a key homodimeric enzyme in the shikimate pathway responsible for the...
13.
Gorman S, DAmico R, Winston D, Boehr D
Adv Exp Med Biol
. 2019 Nov;
1163:359-384.
PMID: 31707711
Our ability to engineer protein structure and function has grown dramatically over recent years. Perhaps the next level in protein design is to develop proteins whose function can be regulated...
14.
Boehr A, Arnold J, Oh H, Cameron C, Boehr D
J Biol Chem
. 2019 Oct;
294(45):16897-16907.
PMID: 31575662
The 2'-C-methyl ribonucleosides are nucleoside analogs representing an important class of antiviral agents, especially against positive-strand RNA viruses. Their value is highlighted by the highly successful anti-hepatitis C drug sofosbuvir....
15.
Gorman S, Boehr D
Biochemistry
. 2019 Sep;
58(39):4058-4069.
PMID: 31498992
In solution, proteins fluctuate among many conformational substates, with their relative free energies determining substate populations and energy barriers determining conformational exchange kinetics. It has been suggested that members of...
16.
Shi J, Perryman J, Yang X, Liu X, Musser D, Boehr A, et al.
Biochemistry
. 2019 Aug;
58(36):3735-3743.
PMID: 31424194
The conserved structural motif D is an important determinant of the speed and fidelity of viral RNA-dependent RNA polymerases (RdRps). Structural and computational studies have suggested that conformational changes in...
17.
ORourke K, Sahu D, Bosken Y, DAmico R, Chang C, Boehr D
Structure
. 2019 Jul;
27(9):1405-1415.e5.
PMID: 31257109
Networks of noncovalent interactions are important for protein structural dynamics. We used nuclear magnetic resonance chemical shift covariance analyses on an inactive variant of the alpha subunit of tryptophan synthase...
18.
ORourke K, Axe J, DAmico R, Sahu D, Boehr D
Front Mol Biosci
. 2018 Nov;
5:92.
PMID: 30467546
Tryptophan synthase is a model system for understanding allosteric regulation within enzyme complexes. Amino acid interaction networks were previously delineated in the isolated alpha subunit (αTS) in the absence of...
19.
20.
Gorman S, Sahu D, ORourke K, Boehr D
Methods
. 2018 Jul;
148:88-99.
PMID: 29958930
Solution-state NMR is an important tool for studying protein structure and function. The ability to probe methyl groups has substantially expanded the scope of proteins accessible by NMR spectroscopy, including...