David C Chan
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Explore the profile of David C Chan including associated specialties, affiliations and a list of published articles.
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107
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18494
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Recent Articles
1.
Yamada T, Ikeda A, Murata D, Wang H, Zhang C, Khare P, et al.
Nature
. 2025 Feb;
PMID: 39972141
Mitochondrial stress pathways protect mitochondrial health from cellular insults. However, their role under physiological conditions is largely unknown. Here, using 18 single, double and triple whole-body and tissue-specific knockout and...
2.
Chan D, Card D, Taylor L
Am Econ Rev
. 2025 Jan;
113(11):3003-3043.
PMID: 39816722
We study public versus private provision of health care for veterans aged 65 and older who may receive care provided by the US Department of Veterans Affairs (VA) and in...
3.
Yang Z, Chan D
ACS Synth Biol
. 2024 Aug;
13(9):2791-2803.
PMID: 39162343
Mitochondria-endoplasmic reticulum contact sites (MERCS) serve as hotspots for important cellular processes, including calcium homeostasis, phospholipid homeostasis, mitochondria dynamics, and mitochondrial quality control. MERCS reporters based on complementation of green...
4.
Li J, Zhu J, Deng Y, Reck E, Walker E, Sidarala V, et al.
bioRxiv
. 2024 Jun;
PMID: 38895283
Proteotoxicity is a contributor to the development of type 2 diabetes (T2D), but it is unknown whether protein misfolding in T2D is generalized or has special features. Here, we report...
5.
Castellaneta A, Losito I, Porcelli V, Barile S, Maresca A, Del Dotto V, et al.
J Lipid Res
. 2024 May;
65(6):100563.
PMID: 38763493
Depletion or mutations of key proteins for mitochondrial fusion, like optic atrophy 1 (OPA1) and mitofusins 1 and 2 (Mfn 1 and 2), are known to significantly impact the mitochondrial...
6.
Yamashita S, Sugiura Y, Matsuoka Y, Maeda R, Inoue K, Furukawa K, et al.
Cell Death Differ
. 2024 Mar;
31(5):651-661.
PMID: 38519771
Mitophagy plays an important role in the maintenance of mitochondrial homeostasis and can be categorized into two types: ubiquitin-mediated and receptor-mediated pathways. During receptor-mediated mitophagy, mitophagy receptors facilitate mitophagy by...
7.
Rosencrans W, Chan D
Mitochondrial Commun
. 2024 Mar;
1:33-34.
PMID: 38515999
No abstract available.
8.
Yang Z, Chan D
bioRxiv
. 2024 Feb;
PMID: 38405790
Mitochondria-ER contact sites (MERCS) serve as hotspots for important cellular processes, including calcium homeostasis, phospholipid homeostasis, mitochondria dynamics, and mitochondrial quality control. MERCS reporters based on complementation of GFP fragments...
9.
Chakrabarty Y, Yang Z, Chen H, Chan D
Mol Cell
. 2024 Feb;
84(6):1090-1100.e6.
PMID: 38340717
To maintain mitochondrial homeostasis, damaged or excessive mitochondria are culled in coordination with the physiological state of the cell. The integrated stress response (ISR) is a signaling network that recognizes...
10.
Fry M, Navarro P, Hakim P, Ananda V, Qin X, Landoni J, et al.
EMBO J
. 2024 Jan;
43(3):391-413.
PMID: 38225406
Cristae membrane state plays a central role in regulating mitochondrial function and cellular metabolism. The protein Optic atrophy 1 (Opa1) is an important crista remodeler that exists as two forms...