Scott A Detmer
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Explore the profile of Scott A Detmer including associated specialties, affiliations and a list of published articles.
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9
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2550
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Recent Articles
1.
Lyman S, Crawley S, Gong R, Adamkewicz J, McGrath G, Chew J, et al.
PLoS One
. 2011 Mar;
6(3):e17692.
PMID: 21408192
Background: Many proteins that are dysregulated or mutated in cancer cells rely on the molecular chaperone HSP90 for their proper folding and activity, which has led to considerable interest in...
2.
Detmer S, Vande Velde C, Cleveland D, Chan D
Hum Mol Genet
. 2007 Oct;
17(3):367-75.
PMID: 17959936
Charcot-Marie-Tooth (CMT) disease type 2A is a progressive, neurodegenerative disorder affecting long peripheral motor and sensory nerves. The most common clinical sign is weakness in the lower legs and feet,...
3.
Detmer S, Chan D
Nat Rev Mol Cell Biol
. 2007 Oct;
8(11):870-9.
PMID: 17928812
Recent findings have sparked renewed appreciation for the remarkably dynamic nature of mitochondria. These organelles constantly fuse and divide, and are actively transported to specific subcellular locations. These dynamic processes...
4.
Detmer S, Chan D
J Cell Biol
. 2007 Feb;
176(4):405-14.
PMID: 17296794
Mfn2, an oligomeric mitochondrial protein important for mitochondrial fusion, is mutated in Charcot-Marie-Tooth disease (CMT) type 2A, a peripheral neuropathy characterized by axonal degeneration. In addition to homooligomeric complexes, Mfn2...
5.
Griffin E, Detmer S, Chan D
Biochim Biophys Acta
. 2006 Mar;
1763(5-6):482-9.
PMID: 16571363
Mitochondrial fusion requires coordinated fusion of the outer and inner membranes. This process leads to exchange of contents, controls the shape of mitochondria, and is important for mitochondrial function. Two...
6.
Koshiba T, Detmer S, Kaiser J, Chen H, McCaffery J, Chan D
Science
. 2004 Aug;
305(5685):858-62.
PMID: 15297672
Vesicle fusion involves vesicle tethering, docking, and membrane merger. We show that mitofusin, an integral mitochondrial membrane protein, is required on adjacent mitochondria to mediate fusion, which indicates that mitofusin...
7.
Chen H, Detmer S, Ewald A, Griffin E, Fraser S, Chan D
J Cell Biol
. 2003 Jan;
160(2):189-200.
PMID: 12527753
Mitochondrial morphology is determined by a dynamic equilibrium between organelle fusion and fission, but the significance of these processes in vertebrates is unknown. The mitofusins, Mfn1 and Mfn2, have been...
8.
IgG transcytosis and recycling by FcRn expressed in MDCK cells reveals ligand-induced redistribution
Detmer S, Martin W, Bjorkman P
EMBO J
. 2002 Nov;
21(21):5953.
PMID: 12411512
No abstract available.
9.
IgG transcytosis and recycling by FcRn expressed in MDCK cells reveals ligand-induced redistribution
Ramalingam T, Detmer S, Martin W, Bjorkman P
EMBO J
. 2002 Feb;
21(4):590-601.
PMID: 11847107
The neonatal Fc receptor (FcRn) transports IgG across epithelial cells and recycles serum IgG. FcRn binds IgG at the acidic pH of endosomes and releases IgG at the basic pH...