J Michael McCaffery
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Explore the profile of J Michael McCaffery including associated specialties, affiliations and a list of published articles.
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94
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8531
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Recent Articles
1.
Varuzhanyan G, Chen H, Rojansky R, Ladinsky M, McCaffery J, Chan D
Biochim Biophys Acta Gen Subj
. 2021 Jan;
1865(5):129845.
PMID: 33476744
Background: Mitochondrial fission counterbalances fusion to maintain organelle morphology, but its role during development remains poorly characterized. Mammalian spermatogenesis is a complex developmental process involving several drastic changes to mitochondrial...
2.
Garcia E, Liao P, Tan G, Vevea J, Sing C, Tsang C, et al.
Autophagy
. 2020 Oct;
17(9):2363-2383.
PMID: 33021864
Our previous studies reveal a mechanism for lipid droplet (LD)-mediated proteostasis in the endoplasmic reticulum (ER) whereby unfolded proteins that accumulate in the ER in response to lipid imbalance-induced ER...
3.
Grzesik P, Pryce E, Bhalala A, Vij M, Ahmed R, Etienne L, et al.
Viruses
. 2019 Sep;
11(9).
PMID: 31540043
The herpes simplex virus type 1 (HSV-1) UL37 gene encodes for a multifunctional component of the virion tegument, which is necessary for secondary envelopment in the cytoplasm of infected cells,...
4.
Camacho E, Vij R, Chrissian C, Prados-Rosales R, Gil D, OMeally R, et al.
J Biol Chem
. 2019 May;
294(27):10471-10489.
PMID: 31118223
Melanins are synthesized macromolecules that are found in all biological kingdoms. These pigments have a myriad of roles that range from microbial virulence to key components of the innate immune...
5.
Calzada E, Avery E, Sam P, Modak A, Wang C, McCaffery J, et al.
Nat Commun
. 2019 Mar;
10(1):1432.
PMID: 30926815
Of the four separate PE biosynthetic pathways in eukaryotes, one occurs in the mitochondrial inner membrane (IM) and is executed by phosphatidylserine decarboxylase (Psd1). Deletion of Psd1 is lethal in...
6.
Lewis D, Pruitt H, Jain N, Ciccaglione M, McCaffery J, Xia Z, et al.
Cancer Res
. 2019 Feb;
79(8):1981-1995.
PMID: 30777851
Upregulation of collagen matrix crosslinking directly increases its ability to relieve stress under the constant strain imposed by solid tumor, a matrix property termed stress relaxation. However, it is unknown...
7.
Harris G, Eschment M, Orozco S, McCaffery J, Maclennan R, Severin D, et al.
Arch Toxicol
. 2018 Jun;
92(8):2587-2606.
PMID: 29955902
To date, most in vitro toxicity testing has focused on acute effects of compounds at high concentrations. This testing strategy does not reflect real-life exposures, which might contribute to long-term...
8.
Del Dotto V, Mishra P, Vidoni S, Fogazza M, Maresca A, Caporali L, et al.
Cell Rep
. 2017 Jun;
19(12):2557-2571.
PMID: 28636943
OPA1 is a GTPase that controls mitochondrial fusion, cristae integrity, and mtDNA maintenance. In humans, eight isoforms are expressed as combinations of long and short forms, but it is unclear...
9.
Feng Y, Liu X, Huynh K, McCaffery J, Mao L, Gao S, et al.
Environ Sci Technol
. 2017 May;
51(12):6821-6828.
PMID: 28505437
Heteroaggregation of graphene oxide (GO) with nanometer- and micrometer-sized hematite colloids, which are naturally present in aquatic systems, is investigated in this study. The heteroaggregation rates between GO and hematite...
10.
Wu T, Sagullo E, Case D, Zheng X, Li Y, Hong J, et al.
Cell Metab
. 2016 May;
23(5):921-9.
PMID: 27166949
mtDNA sequence alterations are challenging to generate but desirable for basic studies and potential correction of mtDNA diseases. Here, we report a new method for transferring isolated mitochondria into somatic...