David B West
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Explore the profile of David B West including associated specialties, affiliations and a list of published articles.
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24
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1393
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Recent Articles
1.
Dickinson M, Flenniken A, Ji X, Teboul L, Wong M, White J, et al.
Nature
. 2017 Nov;
551(7680):398.
PMID: 29144450
This corrects the article DOI: 10.1038/nature19356.
2.
Bowl M, Simon M, Ingham N, Greenaway S, Santos L, Cater H, et al.
Nat Commun
. 2017 Oct;
8(1):886.
PMID: 29026089
The developmental and physiological complexity of the auditory system is likely reflected in the underlying set of genes involved in auditory function. In humans, over 150 non-syndromic loci have been...
3.
Meehan T, Conte N, West D, Jacobsen J, Mason J, Warren J, et al.
Nat Genet
. 2017 Jun;
49(8):1231-1238.
PMID: 28650483
Although next-generation sequencing has revolutionized the ability to associate variants with human diseases, diagnostic rates and development of new therapies are still limited by a lack of knowledge of the...
4.
Jung C, Zhang J, Trenchard E, Lloyd K, West D, Rosen B, et al.
Transgenic Res
. 2016 Dec;
26(2):263-277.
PMID: 27905063
The CRISPR/Cas9 system has rapidly advanced targeted genome editing technologies. However, its efficiency in targeting with constructs in mouse zygotes via homology directed repair (HDR) remains low. Here, we systematically...
5.
Dickinson M, Flenniken A, Ji X, Teboul L, Wong M, White J, et al.
Nature
. 2016 Sep;
537(7621):508-514.
PMID: 27626380
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous insight into gene function and congenital disorders. As...
6.
West D, Engelhard E, Adkisson M, Nava A, Kirov J, Cipollone A, et al.
PLoS Genet
. 2016 Feb;
12(2):e1005691.
PMID: 26839965
The unintended consequences of gene targeting in mouse models have not been thoroughly studied and a more systematic analysis is needed to understand the frequency and characteristics of off-target effects....
7.
Reporter Gene Silencing in Targeted Mouse Mutants Is Associated with Promoter CpG Island Methylation
Kirov J, Adkisson M, Nava A, Cipollone A, Willis B, Engelhard E, et al.
PLoS One
. 2015 Aug;
10(8):e0134155.
PMID: 26275310
Targeted mutations in mouse disrupt local chromatin structure and may lead to unanticipated local effects. We evaluated targeted gene promoter silencing in a group of six mutants carrying the tm1a...
8.
Karp N, Meehan T, Morgan H, Mason J, Blake A, Kurbatova N, et al.
PLoS Biol
. 2015 May;
13(5):e1002151.
PMID: 25992600
The Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were developed to address the lack of reproducibility in biomedical animal studies and improve the communication of research findings. While...
9.
West D, Pasumarthi R, Baridon B, Djan E, Trainor A, Griffey S, et al.
Genome Res
. 2015 Jan;
25(4):598-607.
PMID: 25591789
Expression of the bacterial beta-galactosidase reporter gene (lacZ) in the vector used for the Knockout Mouse Project (KOMP) is driven by the endogenous promoter of the target gene. In tissues...
10.
Borowsky A, Bandhuvula P, Kumar A, Yoshinaga Y, Nefedov M, Fong L, et al.
J Lipid Res
. 2012 Jul;
53(9):1920-31.
PMID: 22781001
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid involved in immunity, inflammation, angiogenesis, and cancer. S1P lyase (SPL) is the essential enzyme responsible for S1P degradation. SPL augments apoptosis and is down-regulated...